JAHA:卒中后超重、肥胖与患者生存有啥关系?

2017-06-25 xing.T MedSci原创

由此可见,与正常体重者比较,超重和轻度肥胖者缺血性卒中后有更好的10年生存率,即使排除近期卒中前体重减轻的患者。未知的保护因素可能与卒中前体重适度增加有关。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员利用卒中前多次体重指数(BMI)的可用性测量以及在以社区为基础的样本中采用巢式病例对照设计探究了体重如何影响卒中后存活。

研究人员比较了根据卒中前体重进行分层的参与者的全因死亡率。分别对缺血性卒中和所有卒中进行了分析,并对年龄、性别和BMI匹配的无卒中对照者进行了分析。参与者被根据BMI进行分类,随访了10年。生存情况的差异是通过病例状态的相互作用进行测试。在灵敏度分析中,排除那些卒中前体重降低的患者,研究人员将卒中/匹配前10年内连续2次测量BMI正常的参与者限定为对照组。

有782例卒中患者(年龄为71±9岁, 51%为女性参与者,87%为缺血性卒中患者),2346例对照组(年龄为72±9, 51%为女性参与者)。与体重正常者相比,超重缺血性卒中患者死亡率较低(风险比为0.70,95%可信区间为0.55-0.90,P=0.005)。与正常体重BMI为18.5-25相比,BMI≥25与降低的死亡率之间的相关性在缺血性卒中患者中更加明显,但在排除出血性卒中患者后,相关性有所减弱(病例-对照相互作用分别有P=0.051和P=0.130)。与正常体重正常的参与者相比,缺血性卒中后中度体重增加具有保护性作用(超重风险比为0.72,95%可信区间为0.53-0.99,P=0.041)。

由此可见,与正常体重者比较,超重和轻度肥胖者缺血性卒中后有更好的10年生存率,即使排除近期卒中前体重减轻的患者。未知的保护因素可能与卒中前体重适度增加有关。

原始出处:

Hugo J. Aparicio,et al. Overweight, Obesity, and Survival After Stroke in the Framingham Heart Study.JAHA.2017. https://doi.org/10.1161/JAHA.116.004721

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    2017-06-28 往日如昨

    继续学习中谢谢

    0

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    2017-06-28 lou.minghong

    学习了,谢谢分享!

    0

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    2017-06-27 zhaohui6731
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    2017-06-26 189****7206

    学习了受益匪浅

    0

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    2017-06-25 thlabcde

    好东西学习了!

    0

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    2017-06-25 1ddf0692m34(暂无匿称)

    学习了,涨知识

    0

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    2017-06-25 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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