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JAMA：在肺癌中用致癌驱动基因多重检测法来选择靶向药物

2014-06-16 马克·G ·克里斯等 中国医学论坛报JAMA专版

肺癌致癌驱动基因多重检测法靶向药物
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意义：致癌驱动基因是癌症发生与维持很重要的基因组改变，致癌驱动基因靶向疗法改变了肺腺癌患者的治疗。肺癌突变联盟(LCMC)成立，通过采用多重检测法从10个基因中检测肺腺癌的驱动基因，以便临床医师能够选择靶向治疗，并在临床试验中纳入患者。  目的：在肺腺癌患者中确定致癌驱动基因(出现)的频率，应用该数据来选择以识别出的驱动基因为靶标的治疗方法，并对生存期进行检测。  设计、场

意义：致癌驱动基因是癌症发生与维持很重要的基因组改变，致癌驱动基因靶向疗法改变了肺腺癌患者的治疗。肺癌突变联盟(LCMC)成立，通过采用多重检测法从10个基因中检测肺腺癌的驱动基因，以便临床医师能够选择靶向治疗，并在临床试验中纳入患者。【原文下载】  目的：在肺腺癌患者中确定致癌驱动基因(出现)的频率，应用该数据来选择以识别出的驱动基因为靶标的治疗方法，并对生存期进行检测。  设计、场所和参与者：2009-2012年期间，从美国14个研究机构纳入患有转移性肺腺癌的患者，这些患者的体能状态评分为0～2分，并检测其肿瘤样本中是否存在10个驱动基因。收集患者、治疗方式和生存期信息。  干预措施：在肿瘤标本中对10个驱动基因进行检测，并将结果用于选择匹配的靶向治疗。  主要转归和检测指标：确定致癌驱动基因(出现)的频率、采用以基因型为导向治疗的患者比例及生存期。  结果：2009-2012年期间，对来自1007例患者的肿瘤样本进行了至少1种(驱动)基因的检测，对733例患者的肿瘤样本中进行了10种驱动基因检测(全基因分型患者)。在733例患者中

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    2015-11-10 小果

    翻译得不错！

    0

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    2014-09-10 fanweitanzhen

    #致癌驱动#

    0

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    2014-12-22 751943081_32627957

    #驱动基因#

    0

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    2014-06-18 lch19850115

    有全文翻译吗

    0

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    2014-06-18 jambiya

    #致癌#

    0

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    2014-06-16 taotaoyanan

    内容很详实

    0

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