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ACTL6A suppresses p21(Cip1)expression to enhance the epidermal squamous cell carcinoma phenotype

期刊: ONCOGENE, 2020; 39 (36)

Epidermal squamous cell carcinoma (SCC) is a common and highly invasive form of cancer. SCC arises due to ultraviolet light exposure and is associated......

SOX18 promotes gastric cancer metastasis through transactivating MCAM and CCL7

期刊: ONCOGENE, 2020; 39 (33)

The therapeutic strategies for advanced gastric cancer (GC) remain unsatisfying and limited. Therefore, it is still imperative to fully elucidate the ......

Melanoma stem cell maintenance and chemo-resistance are mediated by CD133 signal to PI3K-dependent pathways

期刊: ONCOGENE, 2020; 39 (32)

Melanoma stem cells (MSCs) are characterized by their unique cell surface proteins and aberrant signaling pathways. These stemness properties are eith......

Pathomechanisms in schwannoma development and progression

期刊: ONCOGENE, 2020; 39 (32)

Schwannomas are tumors of the peripheral nervous system, consisting of different cell types. These include tumorigenic Schwann cells, axons, macrophag......

RNA-binding motif protein 43 (RBM43) suppresses hepatocellular carcinoma progression through modulation of cyclin B1 expression

期刊: ONCOGENE, 2020; 39 (33)

RNA-binding proteins play key roles in the posttranscriptional regulation of mRNA during cancer progression. Here, we show that RNA-binding motif prot......

p190A RhoGAP induces CDH1 expression and cooperates with E-cadherin to activate LATS kinases and suppress tumor cell growth

期刊: ONCOGENE, 2020; 39 (33)

TheARHGAP35gene encoding p190A RhoGAP (p190A) is significantly altered by both mutation and allelic deletion in human cancer, but the functional impli......

DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation

期刊: ONCOGENE, 2020; 39 (33)

DNA polymerase beta (Pol beta) plays a critical role in DNA base excision repair (BER), which is involved in maintaining genomic stability and in the ......

Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer

期刊: ONCOGENE, 2020; 39 (33)

High grade serous ovarian cancer (HGSOC) is a fatal gynecologic malignancy in the U.S. with limited treatment options. New therapeutic strategies incl......

The BLIMP1-EZH2 nexus in a non-Hodgkin lymphoma

期刊: ONCOGENE, 2020; 39 (28)

Waldenstrom's macroglobulinemia (WM) is a non-Hodgkin lymphoma, resulting in antibody-secreting lymphoplasmacytic cells in the bone marrow and patholo......

Histone chaperone FACT is essential to overcome replication stress in mammalian cells

期刊: ONCOGENE, 2020; 39 (28)

The histone chaperone FACT is upregulated during mammary tumorigenesis and necessary for the viability and growth of breast tumor cells. We establishe......

Knock-out ofHopxdisrupts stemness and quiescence of hematopoietic stem cells in mice

期刊: ONCOGENE, 2020; 39 (28)

HOPX is a stem cell marker in hair follicles and intestines. It was shown critical for primitive hematopoiesis. We previously showed an association be......

beta-catenin S45F mutation results in apoptotic resistance

期刊: ONCOGENE, 2020; 39 (34)

Wnt/beta-catenin signaling is one of the key cascades regulating embryogenesis and tissue homeostasis; it has also been intimately associated with car......

Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer

期刊: ONCOGENE, 2020; 39 (33)

Metastasis is the leading cause of cancer-related death. This multistage process involves contribution from both tumour cells and the tumour stroma to......

Inhibiting Importin 4-mediated nuclear import of CEBPD enhances chemosensitivity by repression of PRKDC-driven DNA damage repair in cervical cancer

期刊: ONCOGENE, 2020; 39 (34)

Cervical cancer (CC) remains highest in the mortality of female reproductive system cancers, while cisplatin (CDDP) resistance is the one of main reas......

AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma

期刊: ONCOGENE, 2020; 39 (34)

Increasing evidence indicates that long non-coding RNAs (lncRNAs) play vital roles in the tumorigenesis and progression of cancers. However, the funct......

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