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An arginine residue in the outer segment of hASIC1a TM1 affects both proton affinity and channel desensitization

期刊: JOURNAL OF GENERAL PHYSIOLOGY, 2021; 153 (5)

Acid-sensing ion channels (ASICs) respond to changes in pH in the central and peripheral nervous systems and participate in synaptic plasticity and pa......

Mechanisms of proton inhibition and sensitization of the cation channel TRPV3

期刊: JOURNAL OF GENERAL PHYSIOLOGY, 2021; 153 (2)

TRPV3 is a temperature-sensitive, nonselective cation channel expressed prominently in skin keratinocytes. TRPV3 plays important roles in hair morphog......

Mitoflash biogenesis and its role in the autoregulation of mitochondrial proton electrochemical potential

期刊: JOURNAL OF GENERAL PHYSIOLOGY, 2019; 151 (6)

Respiring mitochondria undergo an intermittent electrical and chemical excitation called mitochondrial flash (mitoflash), which transiently uncouples ......

JIF:4.26

Binding and structural asymmetry governs ligand sensitivity in a cyclic nucleotide-gated ion channel

期刊: JOURNAL OF GENERAL PHYSIOLOGY, 2019; 151 (10)

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels open more easily when cAMP or cGMP bind to a domain in the intracellular C-terminus......

JIF:4.26

The AKAP Cypher/Zasp contributes to beta-adrenergic/PKA stimulation of cardiac Ca(v)1.2 calcium channels

期刊: JOURNAL OF GENERAL PHYSIOLOGY, 2018; 150 (6)

Stimulation of the L-type Ca2+ current conducted by Ca(v)1.2 channels in cardiac myocytes by the beta-adrenergic/protein kinase A (PKA) signaling path......

JIF:4.26

A forward genetic screen identifies chaperone CNX-1 as a conserved biogenesis regulator of ERG K+ channels

期刊: JOURNAL OF GENERAL PHYSIOLOGY, 2018; 150 (8)

The human ether-a-go-go-related gene (hERG) encodes a voltage-gated potassium channel that controls repolarization of cardiac action potentials. Accum......

JIF:4.26

Lower troponin expression in the right ventricle of rats explains interventricular differences in E-C coupling

期刊: JOURNAL OF GENERAL PHYSIOLOGY, 2022; 154 (3)

Right ventricular cardiomyocytes show shorter action potential and smaller shortening than left cardiomyocytes. Jeon et al. suggest that interventricu......

JIF:2.698

Ion channel regulation of gut immunity

期刊: JOURNAL OF GENERAL PHYSIOLOGY, 2022; 155 (2)

This Review discusses ion channel expression and function in immune cells, residential non-immune cells and neuroimmune interactions in the gut, and h......

JIF:2.698

Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2

期刊: JOURNAL OF GENERAL PHYSIOLOGY, 2017; 149 (2)

Activation of the transient receptor potential melastatin 2 (TRPM2) channel occurs during the response to oxidative stress under physiological conditi......

JIF:3.68

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