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The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity

期刊: NATURE IMMUNOLOGY, 2020; 21 (3)

Cancer cells subvert immune surveillance through inhibition of T cell effector function. Elucidation of the mechanism of T cell dysfunction is therefo......

T cell receptor and cytokine signal integration in CD8(+) T cells is mediated by the protein Themis

期刊: NATURE IMMUNOLOGY, 2020; 21 (2)

T cell homeostasis and functional responsiveness require signals from self-peptide-major histocompatibility complex (self-pMHC) and cytokines, but the......

Stereotyping in East and West: live with it or deal with it?

期刊: NATURE IMMUNOLOGY, 2020; 21 (3)

As a female faculty member with experience at academic institutions in the United States and in China, I reflect on the challenges encountered along t......

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

期刊: NATURE IMMUNOLOGY, 2020; 21 (7)

Disulfiram is an FDA-approved drug for treating alcoholism. Wu and colleagues show that disulfiram can be repurposed to efficiently inhibit pyroptosis......

Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria

期刊: NATURE IMMUNOLOGY, 2020; 21 (7)

Plasmodium parasite-specific antibodies are critical for protection against malaria, yet the development of long-lived and effective humoral immunity ......

Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins

期刊: NATURE IMMUNOLOGY, 2020; 21 (7)

Plasma membranes of animal cells are enriched for cholesterol. Cholesterol-dependent cytolysins (CDCs) are pore-forming toxins secreted by bacteria th......

Redox homeostasis maintained by GPX4 facilitates STING activation

期刊: NATURE IMMUNOLOGY, 2020; 21 (7)

Stimulator-of-interferon genes (STING) is vital for sensing cytosolic DNA and initiating innate immune responses against microbial infection and tumor......

Ancient familial Mediterranean fever mutations in human pyrin and resistance toYersinia pestis

期刊: NATURE IMMUNOLOGY, 2020; 21 (8)

Familial Mediterranean fever is an autoinflammatory disease caused by gain-of-function mutations in the pyrin inflammasome. Kastner and colleagues sho......

Seventeen on inflammation

期刊: NATURE IMMUNOLOGY, 2020; 21 (8)

In October 2005, we, alongside the laboratory of Casey Weaver, identified a third type of helper T cells that produce the cytokine IL-17, important fo......

Make killers sweeter: targeting metabolic checkpoints of NK cells

期刊: NATURE IMMUNOLOGY, 2020; 21 (9)

Group 2 innate lymphoid cells (ILC2s) closely intersect with antitumor immunity. A new study describes how activation of lung-resident ILC2s orchestra......

IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes

期刊: NATURE IMMUNOLOGY, 2020; 21 (10)

Chronic inflammation is a common feature of obesity, with elevated cytokines such as interleukin-1 (IL-1) in the circulation and tissues. Here, we rep......

Single-cell landscape of immunological responses in patients with COVID-19

期刊: NATURE IMMUNOLOGY, 2020; 21 (9)

In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between dis......

ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection

期刊: NATURE IMMUNOLOGY, 2020; 21 (10)

Accurate serology testing is urgently needed to help diagnose SARS-CoV-2 infection. Here Valkenburg and colleagues use a luciferase immunoprecipitatio......

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

期刊: NATURE IMMUNOLOGY, 2020; 21 (10)

Immune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there......

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