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Emerging immune checkpoints in the tumor microenvironment: Implications for cancer immunotherapy

期刊: CANCER LETTERS, 2021; 511 ()

Immune checkpoints within the tumor microenvironment (TME) play important roles in modulating host antitumor immunity. Checkpoint-based immunotherapie......

GABRP sustains the stemness of triple-negative breast cancer cells through EGFR signaling

期刊: CANCER LETTERS, 2021; 514 ()

Effective treatment regimens for triple-negative breast cancer (TNBC) are relatively scarce due to a lack of specific therapeutic targets. Epidermal g......

Resveratrol for cancer therapy: Challenges and future perspectives

期刊: CANCER LETTERS, 2021; 515 ()

Resveratrol (3,4',5-trihydroxy-trans-stilbene) has been expected to ameliorate cancer and foster breakthroughs in cancer therapy. Despite thousands of......

HNRNPC impedes m(6)A-dependent anti-metastatic alternative splicing events in pancreatic ductal adenocarcinoma

期刊: CANCER LETTERS, 2021; 518 ()

Pancreatic ductal adenocarcinoma (PDAC) is a malignancy with poor prognosis due to early metastasis. The aberrant N6-methyladenosine (m(6)A) RNA modif......

ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-beta

期刊: CANCER LETTERS, 2021; 519 ()

ZEB1 is an important transcription factor that plays a critical role in TGF-beta-induced epithelial-mesenchymal transition (EMT) and tumor metastasis.......

Jolkinolide B targets thioredoxin and glutathione systems to induce ROS-mediated paraptosis and apoptosis in bladder cancer cells

期刊: CANCER LETTERS, 2021; 509 ()

Bladder cancer is a clinically heterogeneous disease with a poor prognosis. In the current study, anti-proliferation assay of a Euphorbiaceae diterpen......

Allogeneic hematopoietic cell transplant overcomes the poor prognostic value of CDKN2 deletion in adult B-lineage acute lymphoblastic leukemia

期刊: CANCER LETTERS, 2021; 510 ()

Emerging evidence suggested that CDKN2 deletion was a poor prognosis predictor in adult B-lineage acute lymphoblastic leukemia (B-ALL). Here, we inves......

Extracellular vesicles in the tumor immune microenvironment

期刊: CANCER LETTERS, 2021; 516 ()

Extracellular vesicles (EVs) have gained significant attention in recent decades as major mediators of intercellular communication that are involved i......

Acetylation-induced PCK isoenzyme transition promotes metabolic adaption of liver cancer to systemic therapy

期刊: CANCER LETTERS, 2021; 519 ()

Sorafenib and lenvatinib are approved first-line targeted therapies for advanced liver cancer, but most patients develop acquired resistance. Herein, ......

NHERF4 hijacks Mas-mediated PLC/AKT signaling to suppress the invasive potential of clear cell renal cell carcinoma cells

期刊: CANCER LETTERS, 2021; 519 ()

The Mas receptor has been reported to promote migration and invasion of clear cell renal cell carcinoma (ccRCC) cells via Ang-(1-7)-dependent AKT sign......

Inhibition of ribosomal RNA processing 15 Homolog (RRP15), which is overexpressed in hepatocellular carcinoma, suppresses tumour growth via induction of senescence and apoptosis

期刊: CANCER LETTERS, 2021; 519 ()

Recent studies suggest that RRP15 (Ribosomal RNA Processing 15 Homolog) might be a potential target for cancer therapy. However, the role of RRP15 in ......

Reducing hyperactivated BAP1 attenuates mutant ASXL1-driven myeloid malignancies in human haematopoietic cells

期刊: CANCER LETTERS, 2021; 519 ()

Additional sex combs-like 1 (ASXL1) is frequently mutated in a variety of myeloid malignancies, resulting in expression of a C-terminal-truncated ASXL......

LncCCLM inhibits lymphatic metastasis of cervical cancer by promoting STAU1-mediated IGF-1 mRNA degradation

期刊: CANCER LETTERS, 2021; 518 ()

Cervical cancer (CC) patients with lymph node (LN) metastasis often have an extremely poor prognosis. However, the precise molecular mechanisms involv......

CDK7 inhibition by THZ1 suppresses cancer stemness in both chemonaive and chemoresistant urothelial carcinoma via the hedgehog signaling pathway

期刊: CANCER LETTERS, 2021; 507 ()

Urothelial carcinoma (UC) is the most common type of bladder cancer, with a 5-year survival rate of only 4.6% in metastatic UC. Despite the advances r......

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