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PKC epsilon SUMOylation Is Required for Mediating the Nociceptive Signaling of Inflammatory Pain

期刊: CELL REPORTS, 2020; 33 (1)

Despite the important roles of protein kinase Ce (PKC epsilon) and transient receptor potential vanilloind 1 (TRPV1) in inflammatory hypersensitivity,......

Evasion of Type I Interferon by SARS-CoV-2

期刊: CELL REPORTS, 2020; 33 (1)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host immune response determine coronavirus disease 2019 (COVID-19), but s......

Endoderm-Derived Myeloid-like Metaphocytes in Zebrafish Gill Mediate Soluble Antigen-Induced Immunity

期刊: CELL REPORTS, 2020; 33 (1)

Immune cells in the mucosal barriers of vertebrates are highly heterogeneous in their origin and function. This heterogeneity is further exemplified b......

Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target

期刊: CELL REPORTS, 2020; 33 (2)

Osteogenic suppressors such as Sclerostin not only regulate skeletal development and regeneration but also serve as anti-osteoporosis drug targets. Ho......

Asymmetric Stratification-Induced Polarity Loss and Coordinated Individual Cell Movements Drive Directional Migration of Vertebrate Epithelium

期刊: CELL REPORTS, 2020; 33 (2)

Collective migration is essential for development, wound repair, and cancer metastasis. For most collective systems, "leader cells" determine both the......

Defending against the Type Six Secretion System: beyond Immunity Genes

期刊: CELL REPORTS, 2020; 33 (2)

The bacterial type six secretion system (T6SS) delivers toxic effector proteins into neighboring cells, but bacteria must protect themselves against t......

PPAR alpha Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction

期刊: CELL REPORTS, 2020; 33 (3)

Dendritic cells (DCs) orchestrate the initiation, programming, and regulation of anti-tumor immune responses. Emerging evidence indicates that the tum......

MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway

期刊: CELL REPORTS, 2020; 33 (3)

The immune system is not only required for preventing threats exerted by pathogens but also essential for developing immune tolerance to avoid tissue ......

Structural and Functional Insights into an Archaeal Lipid Synthase

期刊: CELL REPORTS, 2020; 33 (3)

The UbiA superfamily of intramembrane prenyltransferases catalyzes an isoprenyl transfer reaction in the biosynthesis of lipophilic compounds involved......

A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

期刊: CELL REPORTS, 2020; 33 (3)

The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway trigge......

Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass

期刊: CELL REPORTS, 2020; 33 (4)

The exact mechanisms underlying the metabolic effects of bariatric surgery remain unclear. Here, we demonstrate, using a combination of direct and ind......

Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation

期刊: CELL REPORTS, 2020; 33 (4)

Abnormal activation of calcium channels has been shown to play crucial roles in tumor occurrence and development. However, the role of inhibitors targ......

G9a Plays Distinct Roles in Maintaining DNA Methylation, Retrotransposon Silencing, and Chromatin Looping

期刊: CELL REPORTS, 2020; 33 (4)

G9a is a lysine methyltransferase that regulates epigenetic modifications, transcription, and genome organization. However, whether these properties a......

Mitochondrial UQCC3 Modulates Hypoxia Adaptation by Orchestrating OXPHOS and Glycolysis in Hepatocellular Carcinoma

期刊: CELL REPORTS, 2020; 33 (5)

Bioenergetic reprogramming during hypoxia adaption is critical to promote hepatocellular carcinoma (HCC) growth and progression. However, the mechanis......

Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures

期刊: CELL REPORTS, 2020; 33 (5)

Complex febrile seizures (FSs) lead to a high risk of intractable temporal lobe epilepsy during adulthood, yet the pathological process of complex FSs......

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