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Radiosynthesis and preclinical evaluation of [11C]SNX-ab as an Hsp90α,β isoform-selective PET probe for in vivo brain and tumour imaging

期刊: EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1)

Background The molecular chaperone, Hsp90, is a key player in the protein quality control system that maintains homeostasis under cellular stress cond......

In vitro characterisation of [177Lu]Lu-DOTA-C595 as a novel radioimmunotherapy for MUC1-CE positive pancreatic cancer

期刊: EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1)

BackgroundPancreatic ductal adenocarcinoma (PDAC) continues to be a malignancy with an unmet clinical demand. Development of radioimmunoconjugates whi......

Synthesis and evaluation of a novel PET ligand, a GSK'963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain

期刊: EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1)

Background: Receptor interacting protein kinase 1 (RIPK1) is a serine/threonine kinase, which regulates programmed cell death and inflammation. Recent......

Scale down and optimized automated production of [68Ga]68Ga-DOTA-ECL1i PET tracer targeting CCR2 expression

期刊: EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1)

Background Recently it has been identified a short peptide that showed allosteric antagonism against C-C motif chemokine receptor 2 (CCR2) expressed o......

Chromatographic separation of silver-111 from neutron-irradiated palladium target: toward direct labeling of radiotracers

期刊: EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1)

Background. Silver-111 is a promising beta--emitting radioisotope with ideal characteristics for targeted radionuclide therapy and associated single p......

Improved quality control of [177Lu]Lu-PSMA I&T

期刊: EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1)

BackgroundTargeted radionuclide therapy with [Lu-177]Lu-PSMA I&T (zadavotide guraxetan) has proven high efficacy and safety in treating patients w......

Evaluation of the 177mLu-concentration in in-house produced 177Lu-radiopharmaceuticals and commercially available Lutathera®

期刊: EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1)

Background Lu-177-radiopharmaceuticals can contain the metastable impurity [Lu-177m]lutetium with a physical half-life of 160.4 days, in varying conce......

Optimized, automated and cGMP-compliant synthesis of the HER2 targeting [68Ga]Ga-ABY-025 tracer

期刊: EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1)

Background: The Affibody molecule, ABY-025, has demonstrated utility to detect human epidermal growth factor receptor 2 (HER2) in vivo, either radiola......

Intravenous and oral whole body ketone dosimetry, biodistribution, metabolite correction and kinetics studied by (R)-[1-11C] β-hydroxybutyrate ([11C]OHB) PET in healthy humans

期刊: EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1)

Background: Ketones are increasingly recognized as an important and possibly oxygen sparing source of energy in vital organs such as the heart, the br......

Automated synthesis and quality control of [68Ga]Ga-PentixaFor using the Gaia/Luna Elysia-Raytest module for CXCR4 PET imaging

期刊: EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1)

Background[Ga-68]Ga-PentixaFor is a promising radiotracer for positron emission tomography imaging of several human tumors overexpressing the chemokin......

Dosimetry of [18F]TRACK, the first PET tracer for imaging of TrkB/C receptors in humans

期刊: EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1)

Background: Reduced expression or impaired signalling of tropomyosin receptor kinases (Trk receptors) are found in a vast spectrum of CNS disorders. [......

First preclinical evaluation of [225Ac]Ac-DOTA-JR11 and comparison with [177Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs

期刊: EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1)

Background: The [Lu-177]Lu-DOTA-TATE mediated peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs) is sometimes leading to tre......

Imaging of fibrogenesis in the liver by [18F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

期刊: EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1)

Background: Platelet-derived growth factor receptor beta (PDGFR beta) is a receptor overexpressed on activated hepatic stellate cells (aHSCs). Positro......

Good practices for the automated production of 18F-SiFA radiopharmaceuticals

期刊: EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1)

Background: The positron emitting isotope fluorine-18 (F-18) possesses almost ideal physicochemical properties for the development of radiotracers for......

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