TRIM10 binds to IFN-alpha/beta receptor 1 to negatively regulate type I IFN signal transduction

Guo, MM; Cao, WY; Chen, SW; Tian, RY; Wang, LL; Liu, Q; Zhang, LN; Wang, ZH; Zhao, M; Lu, QJ; Zhu, HZ

Zhu, HZ (corresponding author), Hunan Univ, Inst Pathogen Biol & Immunol, Coll Biol, Hunan Prov Key Lab Med Virol,State Key Lab Chemo, Changsha, Peoples R China.; Zhu, HZ (corresponding author), Hunan Prov Tumor Hosp, Res Ctr Canc Prevent & Treatment, Translat Med Res Ctr Liver Canc, Changsha, Peoples R China.

EUROPEAN JOURNAL OF IMMUNOLOGY, 2021; 51 (7): 1762

Abstract

The type I interferon (IFN-I) system is important for antiviral and anticancer immunity. Prolonged activation of IFN/JAK/STAT signaling is closely ass......

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