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Synthesis and in vitro anti-HCV and Antitumor Evaluation of Schisan-dronic Acid Derivatives

期刊: MEDICINAL CHEMISTRY, 2021; 17 (9)

Background: Schisandronic acid (SA), a triterpenoid from fruits of Schisandra sphenanthera, inhibited pan-genotypic HCV entry into human hepatocytes b......

Anti-oxidant and Antiproliferative Activities of Mongolian Medicinal Plant Extracts and Structure Isolation of Gnetin - H Compound

期刊: MEDICINAL CHEMISTRY, 2021; 17 (9)

Background: Reactive oxygen species are involved in the etiology and progress of many kinds of diseases such as cancer, cardiovascular diseases, infla......

Synthesis and Structure-Activity Relationship Studies of N-monosubstituted Aroylthioureas as Urease Inhibitors

期刊: MEDICINAL CHEMISTRY, 2021; 17 (9)

Background: Thiourea is a classical urease inhibitor which is usually used as a positive control, and many N,N'-disubstituted thioureas have been dete......

Synthesis and 4D-QSAR Studies of Alanine Hydroxamic Acid Derivatives as Aminopeptidase N Inhibitors

期刊: MEDICINAL CHEMISTRY, 2021; 17 (6)

Background: As a target for anticancer treatment, aminopeptidase N (APN) shows its overexpression on diverse malignant tumor cells and associates with......

Chalcones: As Potent alpha-amylase Enzyme Inhibitors; Synthesis, In Vitro, and In Silico Studies

期刊: MEDICINAL CHEMISTRY, 2021; 17 (8)

Background: The inhibition of alpha-amylase enzyme is one of the best therapeutic approach for the management of type II diabetes mellitus. Chalcone p......

Prospects for Discovering the Secondary Metabolites of Cordyceps Sensu Lato by the Integrated Strategy

期刊: MEDICINAL CHEMISTRY, 2021; 17 (2)

Background: Some species of Cordyceps sensu lato are famous Chinese herbs with significant biological activities, often used as edible food and tradit......

Design and Synthesis of Arylnaphthalene Lignan Lactone Derivatives as Potent Topoisomerase Inhibitors

期刊: MEDICINAL CHEMISTRY, 2021; 17 (8)

Background: Arylnaphthalene lignan lactones are a class of natural products containing the phenyl-naphthyl skeleton. Some arylnaphthalene lignan lacto......

Molecular Docking Studies Reveal Rhein from rhubarb (Rheum rhabarbarum) as a Putative Inhibitor of ATP-binding Cassette Super-family G member 2

期刊: MEDICINAL CHEMISTRY, 2021; 17 (3)

Background: ATP-binding cassette Super-family G member 2 protein is an active ATP-binding cassette transporter with the potential to combat cancer ste......

Structural Modifications on CORM-3 Lead to Enhanced Anti-angiogenic Properties Against Triple-negative Breast Cancer Cells

期刊: MEDICINAL CHEMISTRY, 2021; 17 (1)

Purpose: Carbon monoxide-releasing molecules (CORMs) are a special class of organometallic complexes that have been reported to offer beneficial effec......

Quantitative Structure Activity/pharmacokinetics Relationship Studies of HIV-1 Protease Inhibitors Using Three Modelling Methods

期刊: MEDICINAL CHEMISTRY, 2021; 17 (4)

Background: HIV-1 protease inhibitor (PIs) is a good choice for AIDS patients. Nevertheless, for PIs, there are several bugs in clinical application, ......

Synthesis and Biological Evaluation of the Matrine Derivatives as a Novel Family of Potential Anticancer Agents

期刊: MEDICINAL CHEMISTRY, 2021; 17 (5)

Background: 'FufangKushen injection' was a Chinese Traditional anticancer drug, which has been widely used to treat cancer in combination with other a......

The Assessment of Interleukin-18 on the Risk of Coronary Heart Disease

期刊: MEDICINAL CHEMISTRY, 2020; 16 (5)

Background: Observational studies support the inflammation hypothesis in coronary heart disease (CHD). As a pleiotropic proinflammatory cytokine, Inte......

Synthesis and Biological Evaluation of 5-benzyl-3-pyridyl-1H-1,2,4-triazole Derivatives as Xanthine Oxidase Inhibitors

期刊: MEDICINAL CHEMISTRY, 2020; 16 (1)

Background: Topiroxostat is an excellent xanthine oxidase (XO) inhibitor, possessing a specific 3,5-diaryl-1,2,4-triazole framework. Objective: The pr......

Design and Synthesis of Novel Sulfonamide-Derived Triazoles and Bio-activity Exploration

期刊: MEDICINAL CHEMISTRY, 2020; 16 (1)

Objective: Due to the incidence of resistance, a series of sulfonamide-derived 1,2,4-triazoles were synthesized and evaluated. Method: The novel sulfo......

Sysnthesis and Assessment of 3-Substituted Phenazines as Novel Antichlamydial Agents

期刊: MEDICINAL CHEMISTRY, 2020; 16 (3)

Background : In the past century, many phenazines were isolated from the marine microorganism, and some of these phenazines possessed potent antibacte......

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