cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis

Wang, LQ; Jin, HJ; Jochems, F; Wang, SY; Lieftink, C; Martinez, IM; De Conti, G; Edwards, F; de Oliveira, RL; Schepers, A; Zhou, YY; Zheng, JJ; Wu, W; Zheng, XL; Yuan, SX; Ling, J; Jastrzebski, K; Dias, MD; Song, JY; Celie, PNH; Yagita, H; Yao, M; Zhou, W; Beijersbergen, RL; Qin, WX; Bernards, R

Wang, LQ; Bernards, R (通讯作者),Oncode Inst, Netherlands Canc Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands.;Qin, WX; Bernards, R (通讯作者),Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes,Sch Med, Shanghai, Peoples R China.

NATURE CANCER, 2022; 3 (11): 1284

Abstract

Senolytics, drugs that kill senescent cells, have been proposed to improve the response to pro-senescence cancer therapies; however, this remains chal......

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