Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator

Luo, GS; Lin, X; Li, ZB; Xiao, MX; Li, XY; Zhang, DY; Xiang, H

Xiang, H (corresponding author), China Pharmaceut Univ, Jiangsu Key Lab Drug Design & Optimizat, State Key Lab Nat Med, Nanjing 210009, Peoples R China.; Zhang, DY (corresponding author), China Pharmaceut Univ, Inst Pharmaceut Sci, Nanjing 210009, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 209 ():

Abstract

Farnesoid X receptor (FXR) agonists are emerging as potential therapeutics for the treatment of various metabolic diseases, as they display multiple e......

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