Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia

Branstrom, A; Cao, LX; Furia, B; Trotta, C; Santaguida, M; Graci, JD; Colacino, JM; Ray, B; Li, WC; Sheedy, J; Mollin, A; Yeh, SR; Kong, RA; Sheridan, R; Baird, JD; O'Keefe, K; Spiegel, R; Goodwin, E; Keating, S; Weetall, M

Weetall, M (通讯作者)，PTC Therapeut Inc, Res, South Plainfield, NJ 07080 USA.

FRONTIERS IN ONCOLOGY, 2022; 12 ():

Abstract

Blocking the pyrimidine nucleotide de novo synthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH) results in the cell cycle arrest and/o......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索