Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy

Sabatos-Peyton, CA; Nevin, J; Brock, A; Venable, JD; Tan, DJ; Kassam, N; Xu, FM; Taraszka, J; Wesemann, L; Pertel, T; Acharya, N; Klapholz, M; Etminan, Y; Jiang, XM; Huang, YH; Blumberg, RS; Kuchroo, VK; Anderson, AC

Anderson, AC (reprint author), Ann Romney Ctr Neurol Dis, Evergrande Ctr Immunol Dis, 60 Fenwood Rd,BTM 10016 F, Boston, MA 02115 USA.

ONCOIMMUNOLOGY, 2018; 7 (2):

Abstract

Both in vivo data in preclinical cancer models and in vitro data with T cells from patients with advanced cancer support a role for Tim-3 blockade in ......

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