CYP2D6 Activity Is Correlated with Changes in Plasma Concentrations of Taurocholic Acid during Pregnancy and Postpartum in CYP2D6 Extensive MetabolizersS

Czuba, LC; Malhotra, K; Enthoven, L; Fay, EE; Moreni, SL; Mao, JN; Shi, YY; Huang, WZ; Totah, RA; Isoherranen, N; Hebert, MF

Hebert, MF (通讯作者)，Univ Washington, Dept Pharm, Pharm, H-375 Hlth Sci Ctr,1959 NE Pacific St,POB 357630, Seattle, WA 98195 USA.;Hebert, MF (通讯作者)，Univ Washington, Dept Pharm, Obstet & Gynecol, H-375 Hlth Sci Ctr,1959 NE Pacific St,POB 357630, Seattle, WA 98195 USA.

DRUG METABOLISM AND DISPOSITION, 2023; 51 (11): 1474

Abstract

Cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of > 20% of marketed drugs. CYP2D6 expression and activity exhibit high interindividual ......

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