Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide

Santamaria, S; Cuffaro, D; Nuti, E; Ciccone, L; Tuccinardi, T; Liva, F; D'Andrea, F; de Groot, R; Rossello, A; Ahnstrom, J

Santamaria, S (corresponding author), Imperial Coll London, Dept Immunol & Inflammat, Du Cane Rd, London W12 0NN, England.; Nuti, E (corresponding author), Univ Pisa, Dept Pharm, Via Bonanno 6, I-56126 Pisa, Italy.

SCIENTIFIC REPORTS, 2021; 11 (1):

Abstract

ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Dysregulated aggrecanase activity of ADAMTS-5 ha......

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