Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

Chen, LL; Morcelle, C; Cheng, ZL; Chen, XF; Xu, YP; Gao, YJ; Song, JB; Li, ZJ; Smith, M; Shi, M; Zhu, YZ; Zhou, N; Cheng, M; He, CX; Liu, KY; Lu, GP; Zhang, L; Zhang, C; Zhang, JY; Sun, YP; Qi, T; Lyu, YY; Ren, ZZ; Tan, XM; Lan, F; Liu, Y; Yang, H; Duan, CW; Chang, X; Zhou, YF; Shen, L; Baldwin, A; Guan, KL; Xiong, Y; Ye, D; Yin, J; Qian, M

Ye, D (通讯作者)，Fudan Univ, Huashan Hosp, Shanghai, Peoples R China.;Ye, D (通讯作者)，Fudan Univ, Shanghai Key Lab Med Epigenet, Int Colab Med Epigenet & Metab, Minist Sci & Technol,Inst Biomed Sci,Shanghai Med, Shanghai, Peoples R China.;Ye, D (通讯作者)，Fudan Univ, Mol & Cell Biol Lab, Inst Biomed Sci, Shanghai Med Coll, Shanghai, Peoples R China.

NATURE CELL BIOLOGY, 2022; 24 (3): 353

Abstract

As one of the most induced genes in activated macrophages, immune-responsive gene 1 (IRG1) encodes a mitochondrial metabolic enzyme catalysing the pro......

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