Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity

Blum, TR; Liu, H; Packer, MS; Xiong, XZ; Lee, PG; Zhang, SC; Richter, M; Minasov, G; Satchell, KJF; Dong, M; Liu, DR

Liu, DR (corresponding author), Broad Inst Harvard & MIT, Merkin Inst Transformat Technol Healthcare, Cambridge, MA 02142 USA.; Liu, DR (corresponding author), Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA.; Liu, DR (corresponding author), Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA.; Dong, M (corresponding author), Boston Childrens Hosp, Dept Urol, Boston, MA 02115 USA.; Dong, M (corresponding author), Harvard Med Sch, Dept Microbiol, Boston, MA 02115 USA.; Dong

SCIENCE, 2021; 371 (6531): 803

Abstract

Although bespoke, sequence-specific proteases have the potential to advance biotechnology and medicine, generation of proteases with tailor-made cleav......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索