MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy

Wang, Y; Luo, W; Han, JB; Khan, ZA; Fang, QL; Jin, YY; Chen, XM; Zhang, YL; Wang, MH; Qian, JC; Huang, WJ; Lum, H; Wu, GJ; Liang, G

Wang, Y; Liang, G (corresponding author), Wenzhou Med Univ, Dept Cardiol, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China.; Wang, Y; Liang, G (corresponding author), Wenzhou Med Univ, Chem Biol Res Ctr, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China.

NATURE COMMUNICATIONS, 2020; 11 (1):

Abstract

Hyperglycemia activates toll-like receptor 4 (TLR4) to induce inflammation in diabetic cardiomyopathy (DCM). However, the mechanisms of TLR4 activatio......

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