Morphine-3-glucuronide causes antinociceptive cross-tolerance to morphine and increases spinal substance P expression

Blomqvist, KJ; Viisanen, H; Ahlstrom, FHG; Jokinen, V; Sidorova, YA; Suleymanova, I; Rauhala, PV; Kalso, EA; Lilius, TO

Lilius, TO (corresponding author), Univ Helsinki, Fac Med, Dept Pharmacol, Haartmaninkatu 8 Biomed 1, Helsinki 00014, Finland.

EUROPEAN JOURNAL OF PHARMACOLOGY, 2020; 875 ():

Abstract

Morphine-3-glucuronide (M3G), the main metabolite of morphine, has been implicated in the development of tolerance and of opioid-induced hyperalgesia,......

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