Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate

Hu, A; Zhang, JZ; Wang, J; Li, CC; Yuan, M; Deng, G; Lin, ZC; Qiu, ZP; Liu, HY; Wang, XW; Wei, PC; He, X; Zhao, XL; Qiu, WW; Song, BL

Zhao, XL; Song, BL (通讯作者)，Wuhan Univ, Coll Life Sci, TaiKang Ctr Life & Med Sci,TaiKang Med Sch, Inst Adv Studies,Hubei Key Lab Cell Homeostasis, Wuhan, Hubei, Peoples R China.;Qiu, WW (通讯作者)，East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Sch Chem & Mol Engn, Shanghai, Peoples R China.

CELL RESEARCH, 2022; 32 (3): 288

Abstract

Hedgehog (Hh) is a morphogen that binds to its receptor Patched 1 and activates Smoothened (SMO), thereby governing embryonic development and postnata......

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