Neddylation stabilizes Na(v)1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models

Chen, WB; Luo, B; Gao, NN; Li, HW; Wang, HS; Li, L; Cui, WP; Zhang, L; Sun, D; Liu, F; Dong, ZQ; Ren, X; Zhang, HS; Su, HB; Xiong, WC; Mei, L

Mei, L (corresponding author), Case Western Reserve Univ, Sch Med, Dept Neurosci, 10900 Euclid Ave, Cleveland, OH 44106 USA.

JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (8):

Abstract

The excitability of interneurons requires Na(v)1.1, the alpha subunit of the voltage-gated sodium channel. Na(v)1.1 deficiency and mutations reduce in......

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