F-18-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446

Koole, M; Schmidt, ME; Hijzen, A; Ravenstijn, P; Vandermeulen, C; Van Weehaeghe, D; Serdons, K; Celen, S; Bormans, G; Ceusters, M; Zhang, W; Van Nueten, L; Kolb, H; de Hoon, J; Van Laere, K

Van Laere, K (reprint author), Univ Hosp Gasthuisberg, Div Nucl Med, Herestr 49, B-3000 Leuven, Belgium.

JOURNAL OF NUCLEAR MEDICINE, 2019; 60 (5): 683

Abstract

The P2X7 receptor (P2X7R) is an adenosine triphosphate-gated ion channel that is predominantly expressed on microglial cells in the central nervous sy......

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