Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1

Khuri, N; Zur, AA; Wittwer, MB; Lin, L; Yee, SW; Sali, A; Giacomini, KM

Giacomini, KM (reprint author), Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA.; Giacomini, KM (reprint author), Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA.

JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2017; 57 (6): 1402

Abstract

Human organic anion transporters (OATPs) are vital for the uptake and efflux of drugs and endogenous compounds. Current identification of inhibitors o......

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