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Targeting KRAS in Solid Tumors: Current Challenges and Future Opportunities of Novel KRAS Inhibitors

KRAS: Druggable at Last

KRAS G12C Game of Thrones, which direct KRAS inhibitor will claim the iron throne?

Radiation combined with KRAS-MEK inhibitors enhances anticancer immunity in KRAS-mutated tumor models

Realgar-induced KRAS mutation lung cancer cell death via KRAS/Raf/MAPK mediates ferroptosis

KRAS(G12C)-independent feedback activation of wild-type RAS constrains KRAS(G12C) inhibitor efficacy

Novel KRAS G12D degrader ASP3082 demonstrates in vivo, dose-dependent KRAS degradation, KRAS pathwayinhibition, and antitumor efficacy in multiple KRAS G12D-mutated cancer models

Targeting KRAS in Colorectal Cancer

KRAS K104 modification affects the KRAS(G12D)-GEF interaction and mediates cell growth and motility

Diffusion kernel-based predictive modeling of KRAS dependency in KRAS wild type cancer cell lines

Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitorof KRAS

Dysregulation of KRAS signaling in pancreatic cancer is not associated with KRAS mutations and outcome

Iron out KRAS-driven cancer

Efforts to Develop KRAS Inhibitors

Targeting KRAS in Pancreatic Cancer

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