JCLA:在系统性红斑狼疮患者中,中性粒细胞‐C3比值和中性粒细胞‐淋巴细胞比值与疾病活性相关

2019-05-16 不详 网络

系统性红斑狼疮易复发,其治疗与疾病活动有关。所以,准确地评估病人的疾病活动是很重要的。因此,本研究的目的是研究系统性红斑狼疮(SLE)患者中性粒细胞‐C3比值(NC3R)、中性粒细胞‐淋巴细胞比值(NLR)与疾病活性之间的关系。

系统性红斑狼疮易复发,其治疗与疾病活动有关。所以,准确地评估病人的疾病活动是很重要的。因此,本研究的目的是研究系统性红斑狼疮(SLE)患者中性粒细胞‐C3比值(NC3R)、中性粒细胞‐淋巴细胞比值(NLR)与疾病活性之间的关系。

这是一项回顾性研究。研究人员将1904SLE患者和71例健康对照纳入本研究。根据SLE疾病活动度(SLEDAI)将患者分为两组。第1组为>评分9(严重疾病活动度)的患者,第2组为9分及以下(轻度疾病活动度)的患者。分析了NC3RNLR与疾病活性的关系。

SLE患者NC3RNLR明显高于正常对照组(P < 0.05)。两组间NC3RNLR差异有统计学意义(P < 0.05)SLEDAI评分与NC3R (r = 0.353, P < 0.01)NLR (r = 0.237, P = 0.01)呈正相关。工作特性(ROC)曲线分析表明,NC3RSLE高疾病活动度的识别截止值为5.935,敏感性和特异性分别为75.9%67.0%NLR2.293,敏感性为68.9%,特异性为82.8%

研究表明,NC3RNLR是评估SLE患者疾病活性的两种有用的炎症标志物。

原始出处:

Jianlin Yu , Tingting Zeng , NeutrophiltoC3 ratio and neutrophiltolymphocyte ratio were associated with disease activity in patients with systemic lupus erythematosus

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