JACC:心脏损伤程度与重度主动脉瓣狭窄患者预后相关

2019-07-31 不详 MedSci原创

在严重主动脉瓣狭窄(AS)患者中,经常会出现瓣膜外的病变。近期探索出了一个基于心脏损伤程度的新的重症AS分级系统。本研究在一个大型的、真实的、多中心的有症状严重AS患者队列中评估了这些心脏损害不同阶段的患病率和预后影响。本研究纳入分析了1189名症状严重的AS患者,并根据心超检测的心脏损伤程度,将患者分为0级(无心脏损伤)、1级(左室损伤)、2级(二尖瓣或左房损伤)、3级(三尖瓣或肺动脉血管损伤)

在严重主动脉瓣狭窄(AS)患者中,经常会出现瓣膜外的病变。近期探索出了一个基于心脏损伤程度的新的重症AS分级系统。本研究在一个大型的、真实的、多中心的有症状严重AS患者队列中评估了这些心脏损害不同阶段的患病率和预后影响。

本研究纳入分析了1189名症状严重的AS患者,并根据心超检测的心脏损伤程度,将患者分为0级(无心脏损伤)、1级(左室损伤)、2级(二尖瓣或左房损伤)、3级(三尖瓣或肺动脉血管损伤)和4级(右室损伤)。最终,共有8%的患者分为0级,24%的患者为1级,49%的为2级,7%的为3级,12%的为4级。经多元回归分析,心脏损伤程度与全因死亡率和复合终点事件(全因死亡率、卒中和心源性住院率)呈独立相关。

研究结果显示,心脏损害程度与严重主动脉瓣狭窄患者的全因死亡率和复合终点事件呈独立相关性。

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    2020-03-02 hbwxf
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