Am J Resp Crit Care:早产儿早期肺血管疾病与儿童呼吸结局相关

2018-10-11 xing.T MedSci原创

由此可见,早产儿PVD早期超声心动图证据联合其它围产期因素是LRD的一个重要危险因素,提示早期PVD可能有助于BPD的病理学机制。

早产儿早期肺血管疾病(PVD)与发生支气管肺发育不良(BPD)的高风险相关,但其与儿童早期呼吸结局的关系仍不确定。近日,呼吸内科以及重症医学领域权威杂志Am J Resp Crit Care上发表了一篇研究文章,研究人员旨在明确早产7天后PVD是否与儿童早期的呼吸道疾病(LRD)相关。

研究人员对停经后34周(PMA)前出生的早产儿进行前瞻性研究。在PMA第7天和第36周进行超声心动图检查。通过logistic回归模型分析了在6、12、18和24个月时获得的产前和早期出生后因素和出院后随访调查数据,以确定LRD的早期危险因素,LRD定义为医生诊断的哮喘、反应性气道疾病、BPD恶化、细支气管炎、肺炎或呼吸相关的住院治疗。

在完成随访的221名受试者(中位PMA27周; IQR为25-28和920g; IQR为770g-1090g)中,61%符合LRD诊断标准。7天时的妊娠糖尿病、机械呼吸机支持(MV)和PVD与LRD相关。 7天时PVD和MV支持的组合是LRD的最强预测因子(OR为8.1;95%CI为3.1-21.9,p<0.001)。模拟的产前和早期出生后因素准确预测了LRD(AUC为0.764)。将PMA36周时的BPD状态添加到模型中并未改变诊断的准确性(AUC为0.771)。

由此可见,早产儿PVD早期超声心动图证据联合其它围产期因素是LRD的一个重要危险因素,提示早期PVD可能有助于BPD的病理学机制。

原始出处:

Peter M. Mourani, et al. Early Pulmonary Vascular Disease in Preterm Infants is Associated with Late Respiratory Outcomes in Childhood. AM J RESP CRIT CARE 2018. https://www.atsjournals.org/doi/abs/10.1164/rccm.201803-0428OC 

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    2018-10-11 天地飞扬

    了解一下,谢谢分享!

    0

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    2018-10-11 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2018-10-11 医者仁心5538

    学习了

    0

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