Diabetic Med:2型糖尿病患者血糖变异的特点?

2018-02-01 MedSci MedSci原创

2型糖尿病患者就诊时血糖变异性的增加与不良结局相关。近日,国际杂志 《Diabetic Med》上在线发表一项关2型糖尿病患者血糖变异的特点的研究。研究人员的目标是确定与2型糖尿病患者就诊时升高的血糖变异性相关的患者特征。 研究人员进行了一项病例对照研究,以确定10 130名2型糖尿病患者的HbA 1c变异性与临床协变量之间的关系。根据4年内获得的最低4个HbA 1c读数,通过两个指标[

2型糖尿病患者就诊时血糖变异性的增加与不良结局相关。近日,国际杂志 《Diabetic Med》上在线发表一项关2型糖尿病患者血糖变异的特点的研究。研究人员的目标是确定与2型糖尿病患者就诊时升高的血糖变异性相关的患者特征。 研究人员进行了一项病例对照研究,以确定10 130名2型糖尿病患者的HbA 1c变异性与临床协变量之间的关系。根据4年内获得的最低4个HbA 1c读数,通过两个指标[ sd和变异系数(CV)] 计算变异性。高和低变异性组被定义为sd或CV 的顶部和底部三分位数,并用于逻辑回归分析一些临床和生化协变量。分析分层为低均值(<53 mmol/mol; 7%)和高均值(≥53 mmol/mol; 7%)HbA 1c组。 研究发现,调查结果在两个HbA 1c组和变异性指标之间是一致的。独立于其他因素的治疗是高HbA 1c变异风险的最强关联的协变量。在低HbA 1c组中观察到六倍风险增加。在高的HbA1c组发现类似的结果,风险度增加三倍(P <0.001)。此外,男性,年龄较小,HDL-胆固醇降低和BMI升高均与升高的血糖变异性相关。 研究表明,强化治疗导致的低均值

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