Diabetic Med:妊娠期糖尿病和肥胖是围产期结局的独立危险因素

2019-04-01 不详 网络

<span style="font-size:9.0pt;font-family:宋体;mso-ascii-theme-font:major-fareast; mso-fareast-theme-font:major-fareast;mso-hansi-theme-font:major-fareast; color:black;mso-bidi-font-weight:bold">近日,国际杂

近日,国际杂志 《Diabetic Med》上在线发表一项关于妊娠期糖尿病和肥胖是围产期结局的独立危险因素瑞典的基于人群的队列研究。评估妊娠期糖尿病GDM)与肥胖对围产期结局的相互作用。

本项基于人群的队列研究排除1998年至2012年间单胎分娩前未患妊娠前糖尿病的妇女。进行Logistic回归分析评估GDMBMI与不良围产期结局及其相互作用的潜在独立关联。主要结局指标包括畸形,死产,围产期死亡率,低Apgar评分,胎儿窘迫,早产和Erb's麻痹。

研究结果包括1,294,006名女性,GDM患病率为1%(n = 14,833)。GDM组的超重/肥胖率为67.7%,非GDM组为36.1%。没有显著性相互作用。患有GDM的女性的后代显著增加了畸形的风险,校正后的比值比(aOR1.1695%置信区间1.06-1.26),早产,aOR 1.861.76-1.98),低Apgar评分,aOR 1.361.10- 1.70),胎儿窘迫,aOR 1.091.02-1.16)和Erb's麻痹aOR 2.261.79-2.86)。没有发现死产或围产期死亡的风险。后代超重(BMI 25-29.9公斤/2),肥胖(BMI 30-34.9公斤/2)和严重肥胖的妇女(BMI35.0公斤/2)所有结果的风险显著增加,包括死产1.511.40-1.62)至2.852.52-3.22)和围产期死亡率1.491.40-1.59)至2.832.54-3.15)。

研究结果显示,GDMBMI之间没有相互作用。较高的BMIGDM是最严重的不良围产期结局的主要独立危险因素。需要更有效的孕前和产前干预措施,以防止患有GDM或高BMI的妇女出现严重的不良妊娠结局。

原始出处:

K. HildénU. HansonM. Perssonet al. Gestational diabetes and adiposity are independent risk factors for perinatal outcomes: a population based cohort study in Sweden

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  5. 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  6. 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  9. 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    2019-04-02 12543c13m83暂无昵称

    谢谢分享

    0

  10. 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    2019-04-02 misszhang

    谢谢MedSci提供最新的资讯

    0

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