DIABETOLOGIA:环境温度的每日增量变化对孕妇β细胞功能和妊娠糖尿病风险的影响

2018-12-02 MedSci MedSci原创

由于妊娠期糖尿病(GDM)的患病率在夏季较高,因此可能反映了环境温度与血糖水平之间的一定关联。然而,温度可能会影响妊娠期葡萄糖代谢的具体暴露和机制仍不清楚。研究人员系统地评估了环境温度和其变化与不同持续时间的暴露时间的关系,在接受产前筛查GDM的女性中,进行β细胞功能,胰岛素敏感性和葡萄糖耐量检测。 来自多伦多(ON,加拿大)的1464名29周的平均妊娠期的女性接受了OGTT,其中318名经

由于妊娠期糖尿病GDM)的患病率在夏季较高,因此可能反映了环境温度与血糖水平之间的一定关联。然而,温度可能会影响妊娠期葡萄糖代谢的具体暴露和机制仍不清楚。研究人员系统地评估了环境温度和其变化与不同持续时间的暴露时间的关系,在接受产前筛查GDM的女性中,进行β细胞功能,胰岛素敏感性和葡萄糖耐量检测。

来自多伦多(ON,加拿大)的146429周的平均妊娠期的女性接受了OGTT,其中318名经诊断患有GDM。研究人员评估血糖,β细胞功能和胰岛素敏感性与18个温度变量的关系:OGTT当天以及714212835424956天的平均温度和温度变化。

结果显示,714212835424956天(而不是平均温度)的温度变化可作为血糖的独立预测因子。这些关系在月平均温度上升(2月至7月)的几个月中很明显,但在下降月份(8 - 1月)则不明显。实际上,在2月至7月,前212835天的温度变化是β细胞功能较差和血糖升高的预测因子。此外,在2月至7月,前21天(OR 1.16,95CI 1.01,1.33)和28天(OR 1.20,95CI 1.03,1.39)的温度变化是GDM的独立预测因子,而平均温度不是。

在孕妇中,葡萄糖耐量试验前3-4周环境温度上升可能与β细胞功能障碍和GDM风险增加有关。

原始出处:

Ravi Retnakaran, Impact of daily incremental change in environmental temperature on beta cell function and the risk of gestational diabetes in pregnant women

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    2018-12-03 misszhang

    谢谢MedSci提供最新的资讯

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