BMJ:青霉素过敏导致耐甲氧西林金黄色葡萄球菌和艰难梭菌感染风险

2018-07-01 zhangfan MedSci原创

研究认为,青霉素类过敏人群的耐甲氧西林金黄色葡萄球菌和艰难梭菌感染风险增加。

近日研究人员考察了青霉素过敏人群的耐甲氧西林金黄色葡萄球菌(MRSA)和艰难梭菌(C difficile)感染风险。

301399名成年基线无MRSA或C difficile 感染人群参与研究,其中64141人存在青霉素过敏史,研究匹配了237258无青霉素过敏史的志愿者。研究的主要终点为MRSA和C difficile事件风险,次要终点为β内酰胺类抗生素和β内酰胺类替代抗生素的使用。

6年随访中,参与者总计1365例发生MRSA感染(青霉素过敏人群442例,对照组923例)和1688例艰难梭菌感染(青霉素过敏人群442例,对照组1246例)。调整后青霉素过敏人群的MRSA感染风险为1.69,艰难梭菌感染风险为1.26。青霉素过敏人群使用大环内酯类的比值比为4.15,林可霉素类为3.89,氟喹诺酮类为2.10,因使用其他类型抗生素导致患者MRSA及艰难梭菌感染风险进一步增加,分别新增55%和35%的感染风险。

研究认为,青霉素类过敏人群的耐甲氧西林金黄色葡萄球菌和艰难梭菌感染风险增加。

原始出处:


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    2018-11-10 gaoxiaoe
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    2018-07-02 sunyl09
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    2018-07-02 张新亮1853311252142e2fm

    好文献学习了

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sun Jul 01 07:02:14 CST 2018, time=2018-07-01, status=1, ipAttribution=)]
    2018-07-01 phoebeyan520

    学习了.谢谢

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sun Jul 01 07:02:14 CST 2018, time=2018-07-01, status=1, ipAttribution=)]
    2018-07-01 明月清辉

    谢谢分享.学习了

    0

  9. 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    2018-07-01 wzb521zf

    一起学习学习

    0

  10. 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    2018-07-01 易水河

    青霉素还是很好的抗生素啊

    0

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青霉素是指分子中含有青霉烷、能破坏细菌的细胞壁并在细菌细胞的繁殖期起杀菌作用的一类抗生素。按其特点可分为 :青霉素G类,耐酶青霉素,广谱青霉素。青霉素是绝大多数医生选用频次较高的抗菌药物,在临床中常常会因为某些合并细菌感染的疾病,而选择青霉素类药物抗感染治疗,那么青霉素类药物种类繁多,你是否能了解青霉素类分类、特点及用法,下面青霉素家族成员纷纷“各抒己见”。一、 青霉素G类:家族成员:青霉素 G

JAMA:青霉素过敏并非永久持续存在

青霉素类药物是一类常用并具有重要临床意义的抗菌药物,目前对“青霉素皮试阳性”、“青霉素过敏”的一些误区妨碍了对该类药物的合理使用