Circ-Heart Fail:新诊断心衰后长期认知功能下降!

2018-03-12 xing.T MedSci原创

由此可见,在心衰诊断后,整体认知能力的下降往往比没有诊断心衰时快。这一发现对临床和公共卫生的影响值得进一步关注。

心力衰竭与认知功能障碍有关。然而,研究人员对心衰诊断后认知功能改变的时间过程、合并症房颤的重要性以及射血分数的作用知之甚少。近日,心血管领域权威杂志Circ-Heart Fail上发表了一篇研究文章,研究人员试图明确心衰发生与认知功能减退发生率之间的关系,同时明确这些差异是否与房颤状态或者与射血分数减少以及射血分数正常有关。

该研究的参与者为4864名年龄≥65岁无心衰和临床卒中的男性和女性,从1989/1990年到1998/1999年期间每年进行认知功能评估。研究人员通过审查出院小结和医疗保险索赔数据,确定了496例心衰患者,并按照标准进行了裁决,采用改良的简易精神状态测验评估了整体认知能力。

在调整后的模型中,模型预测的80岁时诊断的心衰患者5年改良的简易精神状态评分平均下降为10.2分(95%可信区间为8.6-11.8),而80岁至85岁之间的无心衰患者5年改良的简易精神状态评分平均下降为5.8分(95%可信区间为5.3-6.2)。老年人中的相关性强于年轻人,在有无房颤上差异不显著(P=0.084),并且射血分数降低和正常的患者也无显著性差异(P=0.734)。

由此可见,在心衰诊断后,整体认知能力的下降往往比没有诊断心衰时快。这一发现对临床和公共卫生的影响值得进一步关注。

原始出处:


Christa A. Hammond,et al. Long-Term Cognitive Decline After Newly Diagnosed Heart Failure Longitudinal Analysis in the CHS (Cardiovascular Health Study). Circulation:heart failure. 2018. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004476

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    2018-10-15 rgjl
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    2018-03-14 zhaojie88
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    2018-03-14 slcumt
  5. [GetPortalCommentsPageByObjectIdResponse(id=1915279, encodeId=c87b19152e971, content=<a href='/topic/show?id=e381586e94d' target=_blank style='color:#2F92EE;'>#新诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58679, encryptionId=e381586e94d, topicName=新诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b48400, createdName=rgjl, createdTime=Mon Oct 15 08:24:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034325, encodeId=4679203432500, content=<a href='/topic/show?id=2fda91215d2' target=_blank style='color:#2F92EE;'>#认知功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91215, encryptionId=2fda91215d2, topicName=认知功能下降)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Fri Jan 25 19:24:00 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356729, encodeId=3e981356e293b, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Mar 14 11:24:00 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562870, encodeId=f71415628e08c, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Mar 14 11:24:00 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295591, encodeId=1072295591a2, content=心力衰竭与认知功能障碍有关.然而.研究人员对心衰诊断后认知功能改变的时间过程.合并症房颤的重要性以及射血分数的作用知之甚少.近日.心血管领域权威杂志Circ-HeartFail上发表了一篇研究文章.研究人员试图明确心衰发生与认知功能减退发生率之间的关系.同时明确这些差异是否与房颤状态或者与射血分数减少以及射血分数正常有关., beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon Mar 12 21:16:17 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295585, encodeId=1f8e29558586, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfDEeydJz0GlP8O0ngrUX6AYCXFic0XDOOAyeQicIqnOd4TrWSwiagJrsFNYuWC1Uc6iavbS1hWt9xtZAhAqLGHqZyl/0, createdBy=42891977006, createdName=1e17414fm02(暂无匿称), createdTime=Mon Mar 12 20:52:26 CST 2018, time=2018-03-12, status=1, ipAttribution=)]
    2018-03-12 有备才能无患

    心力衰竭与认知功能障碍有关.然而.研究人员对心衰诊断后认知功能改变的时间过程.合并症房颤的重要性以及射血分数的作用知之甚少.近日.心血管领域权威杂志Circ-HeartFail上发表了一篇研究文章.研究人员试图明确心衰发生与认知功能减退发生率之间的关系.同时明确这些差异是否与房颤状态或者与射血分数减少以及射血分数正常有关.

    0

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    2018-03-12 1e17414fm02(暂无匿称)

    学习

    0

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