赵靖平教授发现精神分裂症患者脑功能连接异常

2016-08-05 佚名 中华医学信息导报

近日,Nature 杂志子刊Scientific Reports 杂志连续刊登了中南大学湘雅二医院赵靖平教授课题组在精神分裂症研究领域中的两项重要成果。第一项研究针对精神分裂症患者及其高危人群进行了脑功能连接分析,发现这两种人群共享升高的小脑-默认网络连接,这一发现指出小脑-默认网络在精神疾病脑功能连接机制中的重要作用,而且这种共享的小脑-默认网络连接增高是精神分裂症特征性的改变之一。第二项研究针

近日,Nature 杂志子刊Scientific Reports 杂志连续刊登了中南大学湘雅二医院赵靖平教授课题组在精神分裂症研究领域中的两项重要成果。


第一项研究针对精神分裂症患者及其高危人群进行了脑功能连接分析,发现这两种人群共享升高的小脑-默认网络连接,这一发现指出小脑-默认网络在精神疾病脑功能连接机制中的重要作用,而且这种共享的小脑-默认网络连接增高是精神分裂症特征性的改变之一。


第二项研究针对精神分裂症高危人群进行了脑局部一致性分析,认为这类人群存在右侧额下回和壳核局部一致性的增高以及左侧颞下回局部一致性的降低,而脑部的这种特征性改变具有从正常人群中预测精神分裂症高危人群的潜在应用价值。Scientific Reports 杂志评论认为,这两项研究利用先进的实验分析技术对精神分裂症脑影像学的改变展开探讨并提出了新颖的观点,研究结果不仅为该病的脑病理机制研究提供了重要依据,也为该病的临床诊断提供了新思路。


原始出处:


Wang H, Guo W, Liu F, Wang G, Lyu H, Wu R, Chen J, Wang S, Li L, Zhao J. Patients with first-episode, drug-naive schizophrenia and subjects at ultra-high risk of psychosis shared increased cerebellar-default mode network connectivity at rest. Sci Rep. 2016 May 18;6:26124. doi: 10.1038/srep26124.

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    2016-09-06 李东泽

    很好,不错,以后会多学习

    0

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