AJKD:植物蛋白可降低慢性肾病患者死亡率

2015-12-13 Mechront 译 MedSci原创

研究者分析了来自NHANES III的14,866名参与者的健康信息,其中1,065名慢性肾病患者(eGFR < 60),回忆24小时饮食情况采集相关信息。对非CKD人群平均随访8.6年,死亡率为11.1%,对CKD患者平均随访6.2年,死亡率是59.4%。校正年龄、性别、种族、吸烟、酒精、并发症、BMI、运动情况、总蛋白质摄入、能量摄入后发现,CKD患者饮食里总蛋白中植物蛋白比例增加33%

研究者分析了来自NHANES III的14,866名参与者的健康信息,其中1,065名慢性肾病患者(eGFR < 60),回忆24小时饮食情况采集相关信息。对非CKD人群平均随访8.6年,死亡率为11.1%,对CKD患者平均随访6.2年,死亡率是59.4%。校正年龄、性别、种族、吸烟、酒精、并发症、BMI、运动情况、总蛋白质摄入、能量摄入后发现,CKD患者饮食里总蛋白中植物蛋白比例增加33%,可显著降低死亡率(HR 0.77, 95% CI 0.61 to 0.96) 。

犹他大学医学院的Srinivasan Beddhu说:“众所周知肾功能不好的患者应限制蛋白质摄入以保护肾功能,但是蛋白质对CKD患者整体健康的影响尚不明确。而我们的研究表明,对肾功下降患者,植物蛋白可改善患者健康状况。”共同作者 Xiaorui Chen说:“CKD患者摄入的总蛋白里植物蛋白比例每增加33%,可降低23%的死亡率,该数据是领人惊讶的。不过对eGFR ≥ 60的个体,没有发现如此有益健康的联系。”

该研究表明eGFR < 60的CKD患者饮食中应减少动物蛋白,增加植物蛋白如豆腐或其他豆类的摄入。国家肾脏基金会的科学活动主任Thomas Manley说:“先前有研究表明,相比植物蛋白,摄入动物蛋白肠道会吸收更多的磷。血磷增高会导致CKD患者和一般人群的死亡率增加。这也是摄入高比例CKD患者死亡率更高的一种解释。”

关于肾脏疾病的一些事实:


1.当今1/3的美国成年人是肾脏疾病高危人群;
2.高血压、糖尿病、肾衰家族史、>60岁是肾脏疾病主要危险因素;
3.1/9的美国成年人患有肾脏疾病,并且绝大部分人并不知情;
4.早发现在治疗可有效预防肾脏疾病的进展;
5.控制血压血糖、戒烟、常锻炼、保持健康体重、减少止痛药的使用等可减少肾脏疾病风险。

原始出处:

Xiaorui Chen, Guo Wei, Thunder Jalili,et al.The Associations of Plant Protein Intake With All-Cause Mortality in CKD.AJKD.December 10 2015

Mortality in chronic kidney disease patients reduced by plant protein

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    2017-02-14 1ddf0692m34(暂无匿称)

    植物蛋白可以减少肾功能下降

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=176080, encodeId=0dd41e60808f, content=植物蛋白可以减少肾功能下降, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Feb 14 09:57:05 CST 2017, time=2017-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983464, encodeId=b7de198346461, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Oct 21 17:18:00 CST 2016, time=2016-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745185, encodeId=a1011e451856a, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Aug 04 11:18:00 CST 2016, time=2016-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055934, encodeId=f22c20559345e, content=<a href='/topic/show?id=d088536467a' target=_blank style='color:#2F92EE;'>#慢性肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53646, encryptionId=d088536467a, topicName=慢性肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Tue Jun 21 01:18:00 CST 2016, time=2016-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025789, encodeId=6f2d2025e8969, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Wed Jul 20 04:18:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48457, encodeId=93a14845e07, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:17:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48458, encodeId=b2a248458d1, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:17:00 CST 2015, time=2015-12-26, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=176080, encodeId=0dd41e60808f, content=植物蛋白可以减少肾功能下降, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Feb 14 09:57:05 CST 2017, time=2017-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983464, encodeId=b7de198346461, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Oct 21 17:18:00 CST 2016, time=2016-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745185, encodeId=a1011e451856a, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Aug 04 11:18:00 CST 2016, time=2016-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055934, encodeId=f22c20559345e, content=<a href='/topic/show?id=d088536467a' target=_blank style='color:#2F92EE;'>#慢性肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53646, encryptionId=d088536467a, topicName=慢性肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Tue Jun 21 01:18:00 CST 2016, time=2016-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025789, encodeId=6f2d2025e8969, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Wed Jul 20 04:18:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48457, encodeId=93a14845e07, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:17:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48458, encodeId=b2a248458d1, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:17:00 CST 2015, time=2015-12-26, status=1, ipAttribution=)]
    2015-12-26 hixiaoluo

    好文章,值得看。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=176080, encodeId=0dd41e60808f, content=植物蛋白可以减少肾功能下降, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Feb 14 09:57:05 CST 2017, time=2017-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983464, encodeId=b7de198346461, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Oct 21 17:18:00 CST 2016, time=2016-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745185, encodeId=a1011e451856a, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Aug 04 11:18:00 CST 2016, time=2016-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055934, encodeId=f22c20559345e, content=<a href='/topic/show?id=d088536467a' target=_blank style='color:#2F92EE;'>#慢性肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53646, encryptionId=d088536467a, topicName=慢性肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Tue Jun 21 01:18:00 CST 2016, time=2016-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025789, encodeId=6f2d2025e8969, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Wed Jul 20 04:18:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48457, encodeId=93a14845e07, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:17:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48458, encodeId=b2a248458d1, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:17:00 CST 2015, time=2015-12-26, status=1, ipAttribution=)]
    2015-12-26 hixiaoluo

    好文章,值得看。

    0

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妊娠期糖尿病(gestational diabetes mellitus,GDM),一种为妊娠前已确诊患糖尿病,称“糖尿病合并妊娠”;另一种为妊娠前糖代谢正常或有潜在糖耐量减退、妊娠期才出现或确诊的糖尿病,又称为“妊娠期糖尿病(GDM)”。研究证明,妊娠期糖尿病(GDM)是2型糖尿病、心血管疾病、血管内皮细胞功能紊乱的独立风险因素,但是,关于妊娠期糖尿病与将来母体发生肾脏疾病相关性的研究很少。近来