Int J Cardiovas Imag:新生动脉粥样硬化在药物支架再狭窄中起重要作用

2017-07-31 文韬 中国循环杂志

近日,阜外医院宋雷等发表了两篇文章,提示在药物支架再狭窄发生发展过程中,尤其是晚期支架再狭窄,新生动脉粥样硬化(Neoatherosclerosis)起了重要作用,尤其是对于第一代药物支架作用更为明显。

近日,阜外医院宋雷等发表了两篇文章,提示在药物支架再狭窄发生发展过程中,尤其是晚期支架再狭窄,新生动脉粥样硬化(Neoatherosclerosis)起了重要作用,尤其是对于第一代药物支架作用更为明显。

支架内再狭窄始终是影响介入治疗患者远期预后的重要因素。即使是在药物支架广泛应用的今天,支架再狭窄依旧是晚期支架失败最主要的原因。

研究者利用光学相干断层显像(OCT)检查分析了裸金属支架,第1代与第2代药物支架的再狭窄病变。

通过对171例第2代药物支架再狭窄的回分析显发现,三分之一为早期支架内再狭窄(<1年),再狭窄机制以支架膨胀不全造成的内膜增生为主。三分之二为晚期支架内再狭窄(≥1年),其中新生动脉粥样硬化发生率较高(28.9% vs. 15.8%)。

多因素分析显示支架植入时间超过2年、未应用他汀药物、支架内新生内膜面积>50%是发生新生动脉粥样硬化的独立预测因素。

作者认为,该研究对于进一步深入理解支架再狭窄的发生机制,降低支架失败发生率,改善介入治疗患者远期预后有重要意义。

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    2018-02-09 周周人

    学习..

    0

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content=多因素分析显示支架植入时间超过2年、未应用他汀药物、支架内新生内膜面积>50%是发生新生动脉粥样硬化的独立预测因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon Jul 31 16:20:04 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-08-13 周周人

    学习。

    0

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    2017-08-02 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

    0

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  8. 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content=多因素分析显示支架植入时间超过2年、未应用他汀药物、支架内新生内膜面积>50%是发生新生动脉粥样硬化的独立预测因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon Jul 31 16:20:04 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-08-01 1e10c84am36(暂无匿称)

    文章好好,拜读了

    0

  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Aug 01 09:08:29 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228601, encodeId=38b222860186, content=谢谢,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4fb42098367, createdName=海天青, createdTime=Tue Aug 01 00:20:25 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228506, encodeId=e3622285068f, content=多因素分析显示支架植入时间超过2年、未应用他汀药物、支架内新生内膜面积>50%是发生新生动脉粥样硬化的独立预测因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon Jul 31 16:20:04 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-08-01 海天青

    谢谢,学习了

    0

  10. 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content=多因素分析显示支架植入时间超过2年、未应用他汀药物、支架内新生内膜面积>50%是发生新生动脉粥样硬化的独立预测因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon Jul 31 16:20:04 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-07-31 有备才能无患

    多因素分析显示支架植入时间超过2年、未应用他汀药物、支架内新生内膜面积>50%是发生新生动脉粥样硬化的独立预测因素。

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