PLos One:类风湿性关节炎女性患者步行能力的影响因素

2018-03-29 xiangting MedSci原创

在女性RA患者中,高膝关节伸展力量,低疾病活动度和甲氨喋呤的使用与良好的步行能力密切相关。

这项研究旨在确定与女性类风湿性关节炎(RA)患者步态参数相关的因素。

在一个RA患者的大型队列中进行步态分析,并计算了3种基本的步态参数(步长、节奏和步速)。还收集了临床和实验室检查数据。3个模型中使用强制进入多变量线性回归分析与步态参数相关的因素。然后将健康评估问卷残疾指数(HAQ)评分≤0.5的患者根据其步行速度分为两组,与HAQ评分较好但行走能力差的患者进行比较。

共分析了318名女性患者。膝关节伸展力量与3种步态参数均呈强正相关(P<0.0001),而甲氨蝶呤的使用与3种步态参数均呈正相关(步长:P<0.05,节奏:模型1和2中P <0.05;模型3中P <0.01,步速:P <0.01)。疾病活动评分与步长和步速(步长,步速:模型1和2中P <0.01;模型3中P <0.05)呈负相关。26%HAQ评分良好的患者步行速度缓慢。与HAQ分数良好和步速正常的患者比较,HAQ分数良好、步速缓慢的患者具有更高的疾病活动评分(P<0.05)和更低的膝关节伸展力量(P<0.0001)。

在女性RA患者中,高膝关节伸展力量,低疾病活动度和甲氨喋呤的使用与良好的步行能力密切相关。即使HAQ评分良好,其中约四分之一患者的行走能力差。与步速正常的患者相比,他们的疾病活动度更高,膝关节伸展力量更低。

原始出处:

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    2018-08-31 yuanming15
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createdBy=fda6311, createdName=119337457, createdTime=Wed Sep 05 07:55:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033513, encodeId=3ec72033513e5, content=<a href='/topic/show?id=446044648ad' target=_blank style='color:#2F92EE;'>#女性患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44648, encryptionId=446044648ad, topicName=女性患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Thu Sep 13 02:55:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265660, encodeId=eb7b126566011, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, 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GetPortalCommentsPageByObjectIdResponse(id=1465570, encodeId=e8a314655e0d5, content=<a href='/topic/show?id=144f5032688' target=_blank style='color:#2F92EE;'>#影响因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50326, encryptionId=144f5032688, topicName=影响因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80a06745918, createdName=chenzhuanggui, createdTime=Sat Mar 31 00:55:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483481, encodeId=531d148348179, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Sat Mar 31 00:55:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300848, encodeId=067b30084807, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Mar 29 10:39:17 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300847, encodeId=4fea30084e15, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Mar 29 10:39:12 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300846, encodeId=d4a930084619, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Mar 29 10:39:07 CST 2018, time=2018-03-29, status=1, ipAttribution=)]
    2018-03-31 lmm397
  5. [GetPortalCommentsPageByObjectIdResponse(id=1654823, encodeId=fd1e16548238f, content=<a href='/topic/show?id=4eb6632899b' target=_blank style='color:#2F92EE;'>#步行#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63289, encryptionId=4eb6632899b, topicName=步行)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5524567114, createdName=yuanming15, createdTime=Fri Aug 31 02:55:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1790132, encodeId=94621e901328d, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, 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GetPortalCommentsPageByObjectIdResponse(id=1465570, encodeId=e8a314655e0d5, content=<a href='/topic/show?id=144f5032688' target=_blank style='color:#2F92EE;'>#影响因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50326, encryptionId=144f5032688, topicName=影响因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80a06745918, createdName=chenzhuanggui, createdTime=Sat Mar 31 00:55:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483481, encodeId=531d148348179, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, 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  6. 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  7. 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  8. 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    2018-03-29 xiaotao112411

    学习学习学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1654823, encodeId=fd1e16548238f, content=<a href='/topic/show?id=4eb6632899b' target=_blank style='color:#2F92EE;'>#步行#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63289, encryptionId=4eb6632899b, topicName=步行)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5524567114, createdName=yuanming15, createdTime=Fri Aug 31 02:55:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1790132, encodeId=94621e901328d, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, 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    2018-03-29 xiaotao112411

    学习学习学习

    0

  10. 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    2018-03-29 xiaotao112411

    学习学习学习

    0

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雄激素通常是免疫抑制的,存在未接受治疗的性腺机能减退的男性患者发生自身免疫性疾病的风险增加。到目前为止,尚缺乏去势治疗与自身免疫疾病之间联系的证据。ANN ONCOL近期发表了一篇文章,研究前列腺癌患者去势治疗和类风湿性关节炎之间的关系。