J Glaucoma:阻塞性睡眠呼吸暂停综合征患者患青光眼风险增加——荟萃分析

2015-11-21 QQduhq 译 MedSci原创

既往研究表明,阻塞性睡眠呼吸暂停(OSA)患者患青光眼的几率增加。然而,大多数人并不知道二者的具体关系。本研究旨在通过使用荟萃分析来确定阻塞性睡眠呼吸暂停综合症是否与青光眼有关。

目的:既往研究表明,阻塞性睡眠呼吸暂停(OSA)患者患青光眼的几率增加。然而,大多数人并不知道二者的具体关系。本研究旨在通过使用荟萃分析来确定阻塞性睡眠呼吸暂停综合征是否与青光眼有关。 


方法:
研究人员使用PubMed、荷兰医学文摘、循证医学数据库、Science网络、中国生物医学文献数据库等截至2014年11月20日日的相关文献。通过分析数据,研究人员评估了优势比和95%可信区间(CI)以分析阻塞性睡眠呼吸暂停综合征与青光眼之间的关系。然后进一步分析导致民众患青光眼的类型。
 
结果:
经过筛选,研究人员共选取了6个研究。其中,3例为队列研究,另外3例为病例对照研究。涉及的参与人员共有2288701名。研究表明,阻塞性睡眠呼吸暂停综合征(OSA)和青光眼之间有显著关联。病例对照研究中,OR:2.46;95%CI:1.32——4.59,P = 0.005;队列研究中OR:1.43;95%CI:1.21-1.69,P=0.000。无明显发表偏倚。

结论:
结果表明,阻塞性睡眠呼吸暂停综合征是民众患青光眼的一个危险因素。但研究人员表示,仍然需要进行大量的研究来探索导致阻塞性睡眠呼吸暂停综合征患者罹患青光眼的机制。
 
原始出处:

.Liu S1, Lin Y, et al, Meta-Analysis of Association of Obstructive Sleep Apnea With Glaucoma .J Glaucoma. 2015 Nov 10.

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    2016-06-10 aliceclz
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    2016-02-24 tomyang96
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肥胖是OSA的一个重要的危险因素。本研究旨在评估通过生活方式调整减重计划(LMP)对于中重度OSA患者的效果。这是一个平行组,随机对照试验。共有104例通过便携式家庭睡眠监测诊断为中度至重度OSA的患者随机接受营养师为主导的LMP或常规治疗12个月。主要成果是在12个月时呼吸暂停低通气指数(AHI)减少的评估,通过便携式家用睡眠监测完成。在意向性治疗分析(ITT)中,LMP(n=61)能更有效地从

CHEST:儿童扁桃体切除后阻塞性睡眠呼吸暂停得到缓解?

扁桃体切除术(AT)是治疗儿童阻塞性睡眠呼吸暂停综合征(OSAS)常见的方法,但很少有人知道没有治疗的预后。儿童扁桃体切除术试验(CHAT)随机分配合50%的符合条件的OSAS儿童患者作为对照组(观察等待),并进行7个月的症状随访,身体检查和多导睡眠监测。多导睡眠图及对症解决由呼吸暂停/低通气指数(AHI)<2和阻塞性呼吸暂停指数(OAI)<1,以及OSAS症状评分分别定义(小儿睡眠问

CHEST:OSA的严重程度是房颤发生的独立预测因子

OSA已经是和房颤(AF)相关的常见现象,但来自大型纵向队列数据建立OSA是否是AF独立于肥胖和其他已经建立风险的风险因素的数据还很少。研究人员在1989年和2001年间招募了患者参与睡眠门诊简称为实验室多导睡眠图监测可能的OSA。1970年至2009年之间西澳大利亚全部的人群住院数据被链接到睡眠研究病例中,以确定住院治疗至2009年AF事件。Cox回归分析被用来评估OSA与事件AF的独立相关性。

.Curr Opin Pulm Med:阻塞性睡眠呼吸暂停对中枢神经系统的影响

阻塞性睡眠呼吸暂停(OSA)是一种普遍性的慢性多系统疾病,可能会同时导致许多急性临床问题,包括高血压,肺高压,心血管疾病,葡萄糖不耐受,性功能障碍,胃食管反流以及一系列神经精神和心血管疾病。基于人群的研究显示,高达19%的中年男性和15%的女性可能出现在正常指数之上的呼吸浅慢和呼吸暂停,而大部分患者并未被诊断。 OSA以咽部气道狭窄或梗阻为特征,可由于许多危险因素所致,比如巨舌,扁桃体肥大,