CHEST:儿童扁桃体切除后阻塞性睡眠呼吸暂停得到缓解?

2015-11-04 MedSci MedSci原创

扁桃体切除术(AT)是治疗儿童阻塞性睡眠呼吸暂停综合征(OSAS)常见的方法,但很少有人知道没有治疗的预后。儿童扁桃体切除术试验(CHAT)随机分配合50%的符合条件的OSAS儿童患者作为对照组(观察等待),并进行7个月的症状随访,身体检查和多导睡眠监测。多导睡眠图及对症解决由呼吸暂停/低通气指数(AHI)<2和阻塞性呼吸暂停指数(OAI)<1,以及OSAS症状评分分别定义(小儿睡眠问

扁桃体切除术(AT)是治疗儿童阻塞性睡眠呼吸暂停综合征(OSAS)常见的方法,但很少有人知道没有治疗的预后。

儿童扁桃体切除术试验(CHAT)随机分配合50%的符合条件的OSAS儿童患者作为对照组(观察等待),并进行7个月的症状随访,身体检查和多导睡眠监测。多导睡眠图及对症解决由呼吸暂停/低通气指数(AHI)<2和阻塞性呼吸暂停指数(OAI)<1,以及OSAS症状评分分别定义(小儿睡眠问卷[PSQ])<0.33,从基线开始有≥25%改善。

经过194名5至9岁儿童经历了7个月观察等待后,82(42%)名儿童不再符合OSAS多导睡眠监测标准。对症解决的基线预测因素包括较低的AHI,更好的血氧饱和度,较小的腰围或百分位,高位软腭,小颈围,以及非黑色人种(每个P<0.05)。其中,独立预测因子是较低的AHI和腰围百分<90%。在167名PSQ评分≥0.33的儿童中,只有25(15%)名儿童能够对症解决。基线预测因素为低PSQ和PSQ打鼾分量表得分;无习惯性打鼾,鼾声如雷,观察呼吸暂停,或家庭内部有一个吸烟的人;更高的生活质量;更少的注意力缺失/多动症的症状;和女性发生性关系。只有较低的PSQ和打鼾得分为独立预测因子。

经过7个月的观察等待后,很多AT患者不再有OSAS的多导睡眠监测,然而症状的显著改善却不常见。在实践中,基线较低的AHI和正常的腰围,或低PSQ和打鼾得分,可能有助于确定避免AT的方案。

原始出处:

Ronald D. Chervin,Susan S. Ellenberg,Xiaoling Hou,et al.Prognosis for Spontaneous Resolution of OSA in Children,CHEST,2015.10.28

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    2015-12-19 tomyang96
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    2016-09-04 Smile2680
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