期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; ()
Synthetic analogs based on the DNA bis-intercalatingnatural productpeptides sandramycin and quinaldopeptin were investigated as antibodydrug conjugate......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (14)
Hydrogen sulfide (H2S) is an endogenous gasotransmitterwith anti-inflammatory actions that also reduces itching. To testwhether a combination of an an......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (15)
As an orthogonal principle to the established (hetero)arylhalides,we herein highlight the usefulness of CF2X (X = Cl, Br,or I) moieties. Using tool co......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (15)
The development of histone deacetylase (HDAC) inhibitorsfor treatinghematologic malignancies has been widely investigated, while theirrole in hepatoce......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (17)
Antibiotic resistance caused by biofilm formation isa clinicalchallenge. Nitric oxide (NO) can effectively disperse a mature biofilmand can also syner......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (18)
Current small-molecule PD-1/PD-L1 inhibitors are mainly based on the arylmethylamine/ biphenyl core scaffold. Herein, we designed for the first time a......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (18)
Activated Abelson non-receptor tyrosine kinase (c-Abl) plays a harmful role in neurodegenerative conditions such as Parkinson's disease (PD). Inhibiti......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (20)
The development of cannabinoid receptor type 2 (CB2R) PET radioligands has been intensively explored due to the pronounced CB2R upregulation under var......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (20)
Early in silico assessment of the potential of a series of compounds to deliver a drug is one of the major challenges in computer-assisted drug design......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (20)
Soluble amyloid beta (A beta) aggregates, suggested to be the most toxic forms of A beta, draw attention as therapeutic targets and biomarkers of Alzh......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (21)
Epidermal growth factor receptor (EGFR)-activating mutation is an important oncogenic driver of nonsmall cell lung cancer (NSCLC) patients. Osimertini......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (23)
The MAS-related G(q) protein-coupled receptor X4 (MRGPRX4) is poorly investigated. MRGPRX4 has been proposed to be involved in pain transmission, itch......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (23)
The NLRP3 inflammasome is a multiprotein complex that plays a crucial role in the pathophysiology of multiple inflammation-related diseases. In this s......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (24)
Monopolar spindle kinase 1 (MPS1) plays a pivotal role as a dual-specificity kinase governing spindle assembly checkpoint activation and sister chroma......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2023; 67 (1)
Cryo-electron microscopy (cryo-EM), through resolution advancements, has become pivotal in structure-based drug discovery. However, most cryo-EM struc......
