IBD: 二手烟会增加克罗恩氏病患者肠道手术的风险

2020-07-16 MedSci原创 MedSci原创

尽管有大量证据表明主动吸烟会带来负面影响,但被动吸烟对克罗恩病(CD)病程的影响仍不清楚。本项研究的目的是评估被动吸烟是否是CD肠道手术的危险因素。

背景

尽管有大量证据表明主动吸烟会带来负面影响,但被动吸烟对克罗恩病(CD)病程的影响仍不清楚。本项研究的目的是评估被动吸烟是否是CD肠道手术的危险因素。

 

方法

这项研究是对563例CD患者进行的一项病例对照研究。对接受被动和主动吸烟的患者进行了结构化访谈。对于临床数据,进行了图表检查。回应率为84%,尚待分析471例。为了评估主要目标,即暴露于被动吸烟对肠道手术风险的影响,仅纳入从未主动吸烟的患者。

 

结果

在169例从不主动吸烟的患者中,有91例(54%)暴露于被动吸烟。暴露的患者比未暴露的患者更有可能接受肠道手术(67%vs 30%;P <0.001)。多变量Cox回归分析显示,被动吸烟是肠道手术诊断后的回肠疾病调整后的独立危险因素(危险比,1.7; 95%CI,1.04-2.9;P = 0.034)和在诊断时加强或穿透行为(危险比,1.9; 95%CI,1.2–3.1;P = 0.01)。儿童时期的被动吸烟是晚年成为主动吸烟者的危险因素(优势比为2.2; 95%CI为1.5-3.2;P <0.001)。

 

结论

被动吸烟会增加CD患者肠道手术的风险。

 

原始出处:

Susanna Scharrer. Et al. Passive Smoking Increases the Risk for Intestinal Surgeries in Patients With Crohn’s Disease. Inflammatory Bowel Diseases.2020.

 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1766757, encodeId=65891e66757d1, content=<a href='/topic/show?id=257d8168248' target=_blank style='color:#2F92EE;'>#肠道手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81682, encryptionId=257d8168248, topicName=肠道手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=352d37864233, createdName=12498e5fm24(暂无昵称), createdTime=Sun Jul 26 00:42:28 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003491, encodeId=2851200349165, content=<a href='/topic/show?id=5b592889555' target=_blank style='color:#2F92EE;'>#克罗恩氏病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28895, encryptionId=5b592889555, topicName=克罗恩氏病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=139a316, createdName=wumeihua88, createdTime=Tue Oct 27 00:42:28 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263580, encodeId=bc7c1263580e2, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sat Jul 18 00:42:28 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340134, encodeId=594b1340134cb, content=<a href='/topic/show?id=77b0239266a' target=_blank style='color:#2F92EE;'>#二手烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23926, encryptionId=77b0239266a, topicName=二手烟)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1dfd2500156, createdName=12498c24m69暂无昵称, createdTime=Sat Jul 18 00:42:28 CST 2020, time=2020-07-18, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1766757, encodeId=65891e66757d1, content=<a href='/topic/show?id=257d8168248' target=_blank style='color:#2F92EE;'>#肠道手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81682, encryptionId=257d8168248, topicName=肠道手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=352d37864233, createdName=12498e5fm24(暂无昵称), createdTime=Sun Jul 26 00:42:28 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003491, encodeId=2851200349165, content=<a href='/topic/show?id=5b592889555' target=_blank style='color:#2F92EE;'>#克罗恩氏病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28895, encryptionId=5b592889555, topicName=克罗恩氏病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=139a316, createdName=wumeihua88, createdTime=Tue Oct 27 00:42:28 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263580, encodeId=bc7c1263580e2, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sat Jul 18 00:42:28 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340134, encodeId=594b1340134cb, content=<a href='/topic/show?id=77b0239266a' target=_blank style='color:#2F92EE;'>#二手烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23926, encryptionId=77b0239266a, topicName=二手烟)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1dfd2500156, createdName=12498c24m69暂无昵称, createdTime=Sat Jul 18 00:42:28 CST 2020, time=2020-07-18, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1766757, encodeId=65891e66757d1, content=<a href='/topic/show?id=257d8168248' target=_blank style='color:#2F92EE;'>#肠道手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81682, encryptionId=257d8168248, topicName=肠道手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=352d37864233, createdName=12498e5fm24(暂无昵称), createdTime=Sun Jul 26 00:42:28 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003491, encodeId=2851200349165, content=<a href='/topic/show?id=5b592889555' target=_blank style='color:#2F92EE;'>#克罗恩氏病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28895, encryptionId=5b592889555, topicName=克罗恩氏病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=139a316, createdName=wumeihua88, createdTime=Tue Oct 27 00:42:28 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263580, encodeId=bc7c1263580e2, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sat Jul 18 00:42:28 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340134, encodeId=594b1340134cb, content=<a href='/topic/show?id=77b0239266a' target=_blank style='color:#2F92EE;'>#二手烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23926, encryptionId=77b0239266a, topicName=二手烟)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1dfd2500156, createdName=12498c24m69暂无昵称, createdTime=Sat Jul 18 00:42:28 CST 2020, time=2020-07-18, status=1, ipAttribution=)]
    2020-07-18 bnurmamat
  4. [GetPortalCommentsPageByObjectIdResponse(id=1766757, encodeId=65891e66757d1, content=<a href='/topic/show?id=257d8168248' target=_blank style='color:#2F92EE;'>#肠道手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81682, encryptionId=257d8168248, topicName=肠道手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=352d37864233, createdName=12498e5fm24(暂无昵称), createdTime=Sun Jul 26 00:42:28 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003491, encodeId=2851200349165, content=<a href='/topic/show?id=5b592889555' target=_blank style='color:#2F92EE;'>#克罗恩氏病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28895, encryptionId=5b592889555, topicName=克罗恩氏病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=139a316, createdName=wumeihua88, createdTime=Tue Oct 27 00:42:28 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263580, encodeId=bc7c1263580e2, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sat Jul 18 00:42:28 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340134, encodeId=594b1340134cb, content=<a href='/topic/show?id=77b0239266a' target=_blank style='color:#2F92EE;'>#二手烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23926, encryptionId=77b0239266a, topicName=二手烟)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1dfd2500156, createdName=12498c24m69暂无昵称, createdTime=Sat Jul 18 00:42:28 CST 2020, time=2020-07-18, status=1, ipAttribution=)]

相关资讯

Gastroenterology:Upadacitinib治疗中重度克罗恩病II期临床获得成功

Upadacitinib治疗可提高克中重度克罗恩病患者内镜缓解率

AJG: 新末端回肠的术后内镜复发是克罗恩病的长期预后预测因素

克罗恩病患者术后第一年内进行早期回肠结肠镜检查是评估回肠结肠切除术克罗恩病(CD)复发率的金标准。本项研究的目的是评估术后早期结肠镜检查中吻合口和回肠病变的存在与严重程度与疾病长期预后之间的关系。

JCC:克罗恩病高位肛周瘘管括约肌间瘘管结扎和子宫内膜前移皮瓣的治疗效果分析

括约肌间瘘管[LIFT]和推进皮瓣[AF]的结扎术是治疗克罗恩病瘘的行之有效的手段,他们可以用于保留高位肛周瘘管的括约肌保留术。本研究旨在评估克罗恩氏高肛周瘘管的LIFT和AF后的结局。

Lancet Gastroen Hepatol:腹腔镜回肠切除术 vs英夫利昔单抗治疗回肠炎型克罗恩病

研究支持采用腹腔镜回肠切除术作为克罗恩病的治疗选择,特别是针对局限性(受累节段≤40 cm)和以炎性末端回肠炎为主,常规治疗不成功的患者

JCC:婴儿早期肛周脓肿与克罗恩病的发病率没有关系

儿童有时候也会出现肛周脓肿,而肛周脓肿也恰恰是克罗恩病的临床表现之一,因此,这项研究的目的是在儿童外科手术人群中寻找婴儿肛周脓肿与克罗恩病的发展之间的联系。

IBD:克罗恩病回肠切除吻合术后的吻合口溃疡很常见并且可以预测复发

回肠切除吻合术后克罗恩病的复发很常见。吻合口溃疡是否代表疾病复发并应纳入评分系统尚有争议。这项研究的目的是确定吻合口溃疡对先前进行回盲切除吻合的患者克罗恩病复发的影响。