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中外制药的骨质疏松症治疗药“艾地罗”在中国取得药品注册证书

2020-12-18 国际文传 国际文传

制药公司药品注册
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继日本之后，艾地罗在中国作为骨质疏松症的治疗药物也得到了上市许可。

中外制药株式会社(总公司:东京,代表取缔役会长CEO:小坂达朗)的全资子公司日健中外科技（北京）有限公司（公司：北京市、董事长：三井浩辅）从国家药品监督管理局（NMPA）取得了由总部创新生产的活性维生素D 3衍生物艾地骨化醇软胶囊（商品名：艾地罗®）的药品注册证书，特此通知：
代表取缔役社长COO的奥田修说：“艾地罗作为骨质疏松症的治疗药，取得了NMPA的药品注册证书，我感到非常高兴。”同时也表示“艾地罗在日本作为骨质疏松症治疗药的基本药物获得了高度评价，期待也能给中国的骨质疏松症治疗做出贡献，我们将开始准备进行销售工作。”
据推测，目前中国的骨质疏松症患者约有6900万人。骨质疏松症治疗的目的是预防骨折，防止因骨折而引起的运动器官障碍、内脏功能障碍、卧床不起，维持和改善患者的QOL。因此，医疗现场很需要能够增加骨量和抑制骨折发生的药物。

关于艾地罗
艾地罗是中外制药创新生产的活性维生素D 3衍生物，是具有改善钙代谢和骨代谢作用的药物。在日本，从2011年4月开始以骨质疏松症作为适应症开始销售。在日本国内的《骨质疏松症的预防和治疗指南2015年版》中，作为活性型维生素D3制剂，对于增加骨密度、抑制椎体骨折的有效性评价中获得了A级评价。

上述正文中记载的产品名称受到法律保护。

THE ASIA-PACIFIC REGIONAL AUDIT Epidemiology, cost & burden of osteoporosis in 2013 IOF

关于中外制药
中外制药是专门针对医疗药品的、总公司设立在东京，是东京证券交易所一部上市的领先的生物制药研发型制药公司。作为罗氏集团的重要成员，在国内外开展了积极的医疗药品研发活动，致力于创造满足健康医疗需求的创新型医药品。

原文阅读：http://www.businesswirechina.com/zh/news/45347.html

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    2021-05-16 huhuaidong387

    #注册证书#

    0

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    2020-12-21 ms5000001796948769

    不错

    0

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    2020-12-20 爆笑小医

    #药品注册#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2039849, encodeId=ff4f203984929, content=<a href='/topic/show?id=64d0649e1af' target=_blank style='color:#2F92EE;'>#注册证书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64971, encryptionId=64d0649e1af, topicName=注册证书)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sun May 16 09:41:02 CST 2021, time=2021-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909847, encodeId=945b90984ee4, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e9b75445665, createdName=ms5000001796948769, createdTime=Mon Dec 21 19:14:47 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440622, encodeId=bd7f14406228a, content=<a href='/topic/show?id=eeeb8e444e6' target=_blank style='color:#2F92EE;'>#药品注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87444, encryptionId=eeeb8e444e6, topicName=药品注册)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sun Dec 20 06:41:02 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556905, encodeId=037a1556905df, content=<a href='/topic/show?id=e4016495635' target=_blank style='color:#2F92EE;'>#注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64956, encryptionId=e4016495635, topicName=注册)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c52c14833361, createdName=zhyy93, createdTime=Sun Dec 20 06:41:02 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592656, encodeId=86e41592656d6, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Dec 20 06:41:02 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909197, encodeId=778990919ed4, content=好文章！, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Dec 18 18:01:18 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909173, encodeId=28429091e379, content=对病人是个好消息！, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51935272415, createdName=148267bcm27暂无昵称, createdTime=Fri Dec 18 17:09:28 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909163, encodeId=133d90916326, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Dec 18 16:47:48 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909162, encodeId=383690916240, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210108/6f2c301dd0094c48821b09f39ff8fcd2/63b11becef684756a41de121015c770b.jpg, createdBy=aa152053804, createdName=ydc123456, createdTime=Fri Dec 18 16:38:16 CST 2020, time=2020-12-18, status=1, ipAttribution=)]
    2020-12-20 zhyy93

    #注册#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2039849, encodeId=ff4f203984929, content=<a href='/topic/show?id=64d0649e1af' target=_blank style='color:#2F92EE;'>#注册证书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64971, encryptionId=64d0649e1af, topicName=注册证书)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sun May 16 09:41:02 CST 2021, time=2021-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909847, encodeId=945b90984ee4, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e9b75445665, createdName=ms5000001796948769, createdTime=Mon Dec 21 19:14:47 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440622, encodeId=bd7f14406228a, content=<a href='/topic/show?id=eeeb8e444e6' target=_blank style='color:#2F92EE;'>#药品注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87444, encryptionId=eeeb8e444e6, topicName=药品注册)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sun Dec 20 06:41:02 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556905, encodeId=037a1556905df, content=<a href='/topic/show?id=e4016495635' target=_blank style='color:#2F92EE;'>#注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64956, encryptionId=e4016495635, topicName=注册)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c52c14833361, createdName=zhyy93, createdTime=Sun Dec 20 06:41:02 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592656, encodeId=86e41592656d6, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Dec 20 06:41:02 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909197, encodeId=778990919ed4, content=好文章！, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Dec 18 18:01:18 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909173, encodeId=28429091e379, content=对病人是个好消息！, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51935272415, createdName=148267bcm27暂无昵称, createdTime=Fri Dec 18 17:09:28 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909163, encodeId=133d90916326, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Dec 18 16:47:48 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909162, encodeId=383690916240, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210108/6f2c301dd0094c48821b09f39ff8fcd2/63b11becef684756a41de121015c770b.jpg, createdBy=aa152053804, createdName=ydc123456, createdTime=Fri Dec 18 16:38:16 CST 2020, time=2020-12-18, status=1, ipAttribution=)]
    2020-12-20 Eleven17

    #骨质#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2039849, encodeId=ff4f203984929, content=<a href='/topic/show?id=64d0649e1af' target=_blank style='color:#2F92EE;'>#注册证书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64971, encryptionId=64d0649e1af, topicName=注册证书)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sun May 16 09:41:02 CST 2021, time=2021-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909847, encodeId=945b90984ee4, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e9b75445665, createdName=ms5000001796948769, createdTime=Mon Dec 21 19:14:47 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440622, encodeId=bd7f14406228a, content=<a href='/topic/show?id=eeeb8e444e6' target=_blank style='color:#2F92EE;'>#药品注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87444, encryptionId=eeeb8e444e6, topicName=药品注册)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sun Dec 20 06:41:02 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556905, encodeId=037a1556905df, content=<a href='/topic/show?id=e4016495635' target=_blank style='color:#2F92EE;'>#注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64956, encryptionId=e4016495635, topicName=注册)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c52c14833361, createdName=zhyy93, createdTime=Sun Dec 20 06:41:02 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592656, encodeId=86e41592656d6, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Dec 20 06:41:02 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909197, encodeId=778990919ed4, content=好文章！, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Dec 18 18:01:18 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909173, encodeId=28429091e379, content=对病人是个好消息！, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51935272415, createdName=148267bcm27暂无昵称, createdTime=Fri Dec 18 17:09:28 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909163, encodeId=133d90916326, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Dec 18 16:47:48 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909162, encodeId=383690916240, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210108/6f2c301dd0094c48821b09f39ff8fcd2/63b11becef684756a41de121015c770b.jpg, createdBy=aa152053804, createdName=ydc123456, createdTime=Fri Dec 18 16:38:16 CST 2020, time=2020-12-18, status=1, ipAttribution=)]
    2020-12-18 jyzxjiangqin

    好文章！

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2039849, encodeId=ff4f203984929, content=<a href='/topic/show?id=64d0649e1af' target=_blank style='color:#2F92EE;'>#注册证书#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64971, encryptionId=64d0649e1af, topicName=注册证书)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sun May 16 09:41:02 CST 2021, time=2021-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909847, encodeId=945b90984ee4, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e9b75445665, createdName=ms5000001796948769, createdTime=Mon Dec 21 19:14:47 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440622, encodeId=bd7f14406228a, content=<a href='/topic/show?id=eeeb8e444e6' target=_blank style='color:#2F92EE;'>#药品注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87444, encryptionId=eeeb8e444e6, topicName=药品注册)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sun Dec 20 06:41:02 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556905, encodeId=037a1556905df, content=<a href='/topic/show?id=e4016495635' target=_blank style='color:#2F92EE;'>#注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64956, encryptionId=e4016495635, topicName=注册)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c52c14833361, createdName=zhyy93, createdTime=Sun Dec 20 06:41:02 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592656, encodeId=86e41592656d6, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Dec 20 06:41:02 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909197, encodeId=778990919ed4, content=好文章！, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Dec 18 18:01:18 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909173, encodeId=28429091e379, content=对病人是个好消息！, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51935272415, createdName=148267bcm27暂无昵称, createdTime=Fri Dec 18 17:09:28 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909163, encodeId=133d90916326, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Dec 18 16:47:48 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909162, encodeId=383690916240, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210108/6f2c301dd0094c48821b09f39ff8fcd2/63b11becef684756a41de121015c770b.jpg, createdBy=aa152053804, createdName=ydc123456, createdTime=Fri Dec 18 16:38:16 CST 2020, time=2020-12-18, status=1, ipAttribution=)]
    2020-12-18 148267bcm27暂无昵称

    对病人是个好消息！

    0

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    2020-12-18 医鸣惊人

    认真学习了

    0

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    2020-12-18 ydc123456

    好

    0

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