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JAHA：前列腺素受体2在受损心脏修复中起重要作用

2018-09-28 MedSci MedSci原创

心血管前列腺素受体心肌
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前列腺素E2是公认的免疫调节因子，它在组织受损后释放，并参与调控巨噬细胞的活性，然而前列腺素受体2（EP2）调节的巨噬细胞在心脏缺血后的作用尚不清楚。本研究的目的旨在探究EP2在受损心脏中的作用。本研究利用EP2转基因小鼠模型，发现EP2敲除小鼠的心脏在受损后心功能会更差，并且EP2的缺失会改变促炎反应，导致巨噬细胞聚集于受损心肌的缺陷。转录组分析结果显示红系分化调节蛋白1（Erdr1）在EP2敲

前列腺素E2是公认的免疫调节因子，它在组织受损后释放，并参与调控巨噬细胞的活性，然而前列腺素受体2（EP2）调节的巨噬细胞在心脏缺血后的作用尚不清楚。本研究的目的旨在探究EP2在受损心脏中的作用。

本研究利用EP2转基因小鼠模型，发现EP2敲除小鼠的心脏在受损后心功能会更差，并且EP2的缺失会改变促炎反应，导致巨噬细胞聚集于受损心肌的缺陷。转录组分析结果显示红系分化调节蛋白1（Erdr1）在EP2敲除小鼠中明显上调，敲降Erdr1的表达可以回补EP2敲除细胞的迁移能力。

研究结果显示，前列腺素受体2介导的免疫反应在受损心脏的修复中起到重要作用。

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    2018-10-26 1249884fm96暂无昵称

    #心脏修复#

    0

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    2019-02-19 jiyangfei

    #重要作用#

    0

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    2018-12-04 makuansheng

    #前列腺素#

    0

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    2018-09-30 zhaohui6731

    #AHA#

    0

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    2018-09-28 wxl882001

    学习一下

    0

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