JACC:基于冠脉钙化评分评估他汀药物对心血管预后的影响

2018-12-21 MedSci MedSci原创

与传统危险因素相比,冠脉钙化(CAC)评分可以提高预测动脉粥样硬化性心脏病(ASCVD)预后的准确性,然而,他汀类药物对CAC评分分层的ASCVD结果的相对影响尚不清楚。本研究的目的旨在评估CAC能否识别出最可能受益于他汀类药物的ASCVD患者。本研究纳入了13644名接受有CAC评分的无ASCVD病史和肿瘤病史患者,主要终点事件是主要不良心血管事件(MACE),是急性心梗、卒中和心源性死亡的组合

与传统危险因素相比,冠脉钙化(CAC)评分可以提高预测动脉粥样硬化性心脏病(ASCVD)预后的准确性,然而,他汀类药物对CAC评分分层的ASCVD结果的相对影响尚不清楚。本研究的目的旨在评估CAC能否识别出最可能受益于他汀类药物的ASCVD患者。

本研究纳入了13644名接受有CAC评分的无ASCVD病史和肿瘤病史患者,主要终点事件是主要不良血管事件(MACE),是急性心梗、卒中和心源性死亡的组合事件。经过平均9.4年时间的随访,与未接受他汀类药物治疗的患者相比,他汀类药物可以降低CAC患者的MACE发生率(HR:0.76; 95% Cl: 0.60  0.95; p=0.015),但对无CAC的患者无影响。他汀药物对MACE的影响与CAC的严重程度呈明显相关性(p< 0.0001)。

研究结果显示,在无基础动脉粥样硬化性心脏病的人群中,冠脉钙化的存在和严重程度可以预测他汀药物的保护作用。

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    2019-10-31 hbwxf
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    2018-12-21 1dd8a7c5m95(暂无匿称)

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