Hypertension:儿童期或青少年期血压升高与成年时心血管疾病结局

2020-03-02 xing.T MedSci原创

总之,该系统评价和荟萃分析证实,儿童或青少年BP升高与成年时心血管疾病的一些中间指标和直接结局有关。这些发现强调了维持儿童和青少年血压正常的重要性。

关于儿童或青少年期血压升高与成年后心血管疾病发病率和死亡率之间的关联程度尚不确定。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员旨在总结有关儿童或青少年血压升高对成年后心血管疾病发病率和死亡率长期影响的证据。

研究人员检索了PubMed和Embase数据库,截至2019年8月1日,研究人员对检索到的研究进行了人工审查。该系统评价纳入了所有关于儿童或青少年BP状况与成人心血管疾病的中间指标或直接结局之间关联的所有前瞻性队列研究,包括高脉搏波速度、较厚的颈动脉内膜中层厚度、左心室肥大和心血管疾病疾病(致命和非致命)以及总死亡率。

该系统评价最终共纳入19篇文献,通过荟萃分析可合成分析12篇。在儿童期或青春期血压升高与成年期较高的脉搏波速度(3篇文献,N=3725;合并比值比[OR]为1.83[95%CI为1.39-2.40])、较厚的颈内膜中膜厚度(2篇文献,N=4152;OR为1.60 [95%CI为1.29–2.00])、左室肥厚(2篇文献,N=3019;OR为1.40 [95%CI为1.20-1.64])显著相关。此外,该系统评价还发现青年时期BP升高与成年时心血管疾病发生率和死亡率相关的证据。

总之,该系统评价和荟萃分析证实,儿童或青少年BP升高与成年时心血管疾病的一些中间指标和直接结局有关。这些发现强调了维持儿童和青少年血压正常的重要性。

原始出处:

Lili Yang.et al.Elevated Blood Pressure in Childhood or Adolescence and Cardiovascular Outcomes in Adulthood A Systematic Review.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.14168

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