Brit J Cancer：腰围与23种部位特异性癌症风险的关种

2018-10-18 xing.T MedSci原创

由此可见，中心性肥胖与几种癌症的风险相关，并且独立于一般性肥胖。BMI介导作用的异质性表明不同的机制与不同的癌症部位相关。基于这些发现，应采取积极的策略来监测和预防中心性肥胖。

腰围（WC）增大是几种部位特异性癌症的危险因素，但尚未对针对潜在混杂因素调整的所有常见癌症进行大规模系统研究。近日，肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章，该研究旨在评估WC与常见癌症之间可能存在的联系。

在一项针对近2290万韩国成年人的7年队列研究中，研究人员前瞻性地评估了WC与癌症风险之间的关系。通过使用与国家健康检查数据合并的索赔数据库，研究人员拟合比例风险模型来调查WC与23种最常见癌症之间的关联，并调整潜在的混杂因素，包括体重指数（BMI）。研究人员还评估了BMI对WC与癌症发病率之间关系的修饰作用。

该研究共确定了769871例癌症病例。WC与23种癌症中的18种呈正相关，并且每种性别的影响因部位而异。BMI对WC与癌症之间的关系的修饰作用在整个癌症部位也有所不同；在大多数情况下，它减弱了这种相关性。对于口腔、喉部、食道、肺脏和绝经前乳房的癌症，BMI调整将这种相关性逆转为正相关（所有趋势P<0.001）。

由此可见，中心性肥胖与几种癌症的风险相关，并且独立于一般性肥胖。BMI介导作用的异质性表明不同的机制与不同的癌症部位相关。基于这些发现，应采取积极的策略来监测和预防中心性肥胖。

原始出处：

Kyu Rae Lee,et al. Waist circumference and risk of 23 site-specific cancers: a population-based cohort study of Korean adults.British Journal of Cancer. 2018. https://www.nature.com/articles/s41416-018-0214-7

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#插入话题

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2018-11-03 jinweidong

#特异性#

25 0
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2018-12-20 zhouqu_8

#部位特异性#

42 0
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2018-10-20 naiwu77

#腰围#

36 0
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2018-10-19 kafei

了解一下谢谢

69 0
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2018-10-18 天地飞扬

了解一下，谢谢分享！

66 0
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2018-10-18 医者仁心5538

学习了

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