Heart:老年男性主动脉瓣钙化和心血管危险因素分析

2021-09-03 MedSci原创 MedSci原创

在60-74岁的一般男性人群中AVC普遍存在,并且与所有可改变的心血管危险因素显著相关。

主动脉瓣钙化(AVC)和冠状动脉钙化(CAC)是血管疾病(CVD)的预测因子,可能具有共同的风险因素。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在明确60-74岁男性人群中AVC的患病率,并评估AVC与心血管危险因素(包括CAC和生物标志物)之间的关联。

来自丹麦心脏血管筛查和干预试验(DANCAVAS)具有AVC和CAC评分且之前未进行瓣膜置换的参与者被纳入研究。研究人员根据参与者非对比CT扫描结果计算了钙化评分。心血管危险因素是通过自我报告、测量或两者同时进行,并使用描述性和回归分析进一步探索了与AVC之间的关联。


该研究纳入了14073名年龄在60-74岁之间的男性。AVC评分范围为0到9067AU,平均AVC为6AU(IQR为0-82)。在8156名(58.0%)参与者中,AVC得分>0,215名(1.5%)参与者的AVC得分≥1200。在回归分析中,所有心血管危险因素都与AVC相关;然而,在纳入CAC≥400的参与者后,只有年龄(预期计数比(REC)为1.07(95%CI为1.06至1.09))、高血压(REC为1.24(95%CI为1.09至1.41))、肥胖(REC为1.34(95%CI为1.20至1.50))、已知CVD(REC为1.16(95%CI为1.03至1.31))和血清磷酸盐(REC为2.25(95%CI为1.66至3.10)仍然与其显著相关,而吸烟、糖尿病、高脂血症、估计肾小球滤过率率和血钙则没有。
 
由此可见,在60-74岁的一般男性人群中AVC普遍存在,并且与所有可改变的心血管危险因素显著相关。

原始出处:

Lida Khurrami.et al.Cross-sectional study of aortic valve calcification and cardiovascular risk factors in older Danish men.heart.2021.https://heart.bmj.com/content/early/2021/08/12/heartjnl-2021-319503

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  5. 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createdTime=Sun Sep 05 11:43:36 CST 2021, time=2021-09-05, status=1, ipAttribution=)]
    2021-09-05 zhaojie88
  6. 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  7. 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    2021-09-05 slcumt
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