Hypertension:左心室肥厚和重塑以及认知功能障碍和痴呆症的风险!

2018-01-30 xing.T MedSci原创

总之,在基线时没有临床检测到的心血管疾病和痴呆症的多民族队列研究中,LV肥厚和向心性重构与痴呆症和认知障碍事件独立相关。

在基线时没有临床上认可的心血管疾病的大型人群中,对于左心室(LV)结构和功能与未来认知功能障碍和痴呆症之间的纵向相关性的信息十分有限。近日,心血管权威杂志Hypertension上发表了一篇研究文章,该研究的目的是调查MESA(多种族动脉粥样硬化研究)队列中心脏结构和功能与痴呆症和认知障碍风险之间的关系。

在4999名基线时没有临床诊断心血管疾病和痴呆的参与者中,研究人员使用基线磁共振成像测定LV结构和功能指标。从住院病历记录中确定可能发生的临床痴呆事件。研究人员使用整体认知功能、处理速度和记忆来评估认知功能,并使用调整了人口统计指标、心血管危险因素和心血管事件的Cox比例风险回归模型来评估LV结构和功能指标与临床诊断的痴呆和认知表现的发生率之间的相关性。

在平均随访12年期间,研究人员共记录到130例可能发生的痴呆病例。较高的LV质量指数(风险比为1.01; 95%可信区间为1.00-1.02)和左心室质量与体积比(风险比为2.37; 95%可信区间为1.25-4.43)与痴呆和认知功能受损的事件之间存在独立相关。LV功能指标与痴呆或认知障碍的风险无关。

总之,在基线时没有临床检测到的心血管疾病和痴呆症的多民族队列研究中,LV肥厚和向心性重构与痴呆症和认知障碍事件独立相关。

原始出处:


Kasra Moazzami,et al. Left Ventricular Hypertrophy and Remodeling and Risk of Cognitive Impairment and Dementia MESA (Multi-Ethnic Study of Atherosclerosis). Hypertension.2018. https://doi.org/10.1161/HYPERTENSIONAHA.117.10289

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    2018-11-25 Boyinsh
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  5. 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    2018-12-08 feather89
  6. 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  8. 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  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283530, encodeId=1f4628353051, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Tue Jan 30 15:20:38 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-01-30 天地飞扬

    学习了.谢谢分享!

    0

  10. 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    2018-01-30 海之蓝

    学习

    0

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目前尚不清楚超出推荐值的强化血压(BP)降低是否会导致高血压患者的左心室肥大(LVH)风险降低;也尚不清楚,LVH的风险降低是否可以解释在这个人群中所报告的对心血管疾病( CVD)的益处。近期,一项发表在杂志Circulation上的研究分析了8,164名具有高血压但无糖尿病的参与者(平均年龄67.9岁,女性35.3%,31.2%黑人)的收缩期血压干预(SPRINT)试验;4,086名参与者随机分

J Hypertens:肾动脉狭窄和左心室肥厚有啥关系?

该荟萃分析表明与高血压患者相比,RAS患者左心室肥厚的可能性增加,肾动脉血运重建对左心室结构具有有益的效应,是通过左心室重量指数显著降低来反映。