SCI REP:中性粒细胞与淋巴细胞比值基础值与变化值对肿瘤患者预后的影响!

2017-04-09 xing.T MedSci原创

总之,基础NLR和ΔNLR是接受化疗的晚期胰腺癌患者患者的独立预后预测因素。

胰腺癌是美国男性和女性中因肿瘤死亡的第四大死因。一般而言,诊断为晚期胰腺癌患者的治疗方案较为有限。患者的5年生存率也低于5%。中性粒细胞-淋巴细胞比值(NLR)已被证实与多种肿瘤的预后相关。近日,Scientific reports 杂志上发表了一篇研究文章,研究人员旨在评估接受化疗的晚期胰腺癌患者基础NLR和NLR变化值(ΔNLR)的预后作用。

在2010年1月至2015年6月期间,132名接受化疗的患者符合评估条件。基于该研究中患者的数据,根据接受者操作特征曲线NLR的临界值为2.78。研究人员观察到高水平的基础NLR(NLR>2.78)对总体生存而言是一个不良预后因素(多变量风险比为2.648,P<0.001)。进行2个周期的化疗后增加的NLR(ΔNLR>0)与更高的不良预后风险相关,相比于ΔNLR≤0的患者(多变量风险比为1.894,P=0.007)。结合NLR和ΔNLR因素,多因素分析显示2个周期的化疗后高基础NLR和增加的NLR患者风险显著增加(风险比为5.817,P<0.001),相比于基础NLR较低和ΔNLR<0的患者。

总之,基础NLR和ΔNLR是接受化疗的晚期胰腺癌患者患者的独立预后预测因素。

原始出处:

Yang Chen, et al. Significance of baseline and change in neutrophil-to-lymphocyte ratio in predicting prognosis: a retrospective analysis in advanced pancreatic ductal adenocarcinoma. Scientific reports. 2017. http://www.nature.com/articles/s41598-017-00859-5

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content=目前炎症指标与肿瘤预后是研究热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Mon Apr 10 08:18:43 CST 2017, time=2017-04-10, status=1, ipAttribution=)]
    2017-04-11 Jianghuiqin

    确实如此 这也是反应了免疫对肿瘤的反应~

    0

  6. 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    2017-04-11 daiyaozu

    涨知识了

    0

  7. 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level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/9UjCmequjU9kCytPkWBv9Vm86ERcKqLLofs7pxF08oTIxCetw6gcpg/0, createdBy=2ec72033896, createdName=bing010305, createdTime=Mon Apr 10 11:19:12 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186378, encodeId=17ce1863e8ed, content=好好学习,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Mon Apr 10 09:25:55 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186350, encodeId=a40418635003, content=目前炎症指标与肿瘤预后是研究热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Mon Apr 10 08:18:43 CST 2017, time=2017-04-10, status=1, ipAttribution=)]
    2017-04-10 1ddf3e1dm99(暂无匿称)

    学习了,谢谢

    0

  8. 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level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/9UjCmequjU9kCytPkWBv9Vm86ERcKqLLofs7pxF08oTIxCetw6gcpg/0, createdBy=2ec72033896, createdName=bing010305, createdTime=Mon Apr 10 11:19:12 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186378, encodeId=17ce1863e8ed, content=好好学习,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Mon Apr 10 09:25:55 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186350, encodeId=a40418635003, content=目前炎症指标与肿瘤预后是研究热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Mon Apr 10 08:18:43 CST 2017, time=2017-04-10, status=1, ipAttribution=)]
    2017-04-10 bing010305

    对临床实用值得共享

    0

  9. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhQkEvDREF6S2vZq3ZIpUYjdqicKVoAWaJSGoe8xNvS6o6QpmOlh2AQ7xuUpj8NiaDjJJgjbc7Xj3T6/0, createdBy=1c242047915, createdName=daiyaozu, createdTime=Tue Apr 11 00:09:27 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186468, encodeId=be9f186468ff, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJicFGXtYqfjGiaibNdjOiaRgkexnXiciaDeXaLiaKicovcicDugdYwRPSnQj3FlfXBwVLB5ANB9PGFyB0kraQ/0, createdBy=35b01663265, createdName=1ddf3e1dm99(暂无匿称), createdTime=Mon Apr 10 20:59:54 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186419, encodeId=ab5118641909, content=对临床实用值得共享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/9UjCmequjU9kCytPkWBv9Vm86ERcKqLLofs7pxF08oTIxCetw6gcpg/0, createdBy=2ec72033896, createdName=bing010305, createdTime=Mon Apr 10 11:19:12 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186378, encodeId=17ce1863e8ed, content=好好学习,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Mon Apr 10 09:25:55 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186350, encodeId=a40418635003, content=目前炎症指标与肿瘤预后是研究热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Mon Apr 10 08:18:43 CST 2017, time=2017-04-10, status=1, ipAttribution=)]
    2017-04-10 shaosai

    好好学习,涨知识

    0

  10. 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level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/9UjCmequjU9kCytPkWBv9Vm86ERcKqLLofs7pxF08oTIxCetw6gcpg/0, createdBy=2ec72033896, createdName=bing010305, createdTime=Mon Apr 10 11:19:12 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186378, encodeId=17ce1863e8ed, content=好好学习,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Mon Apr 10 09:25:55 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186350, encodeId=a40418635003, content=目前炎症指标与肿瘤预后是研究热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Mon Apr 10 08:18:43 CST 2017, time=2017-04-10, status=1, ipAttribution=)]
    2017-04-10 tofsw

    目前炎症指标与肿瘤预后是研究热点

    0

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尽管相关报告认为,高中性粒细胞/淋巴细胞值(NLR)为各种肿瘤患者较差生存的预测因素,但尚未对肝细胞癌(HCC)患者进行过深入考察。对此,日本九州大学Ken Shirabe博士等人进行了一项研究,该研究针对因HCC而接受肝脏切除治疗的患者,旨在阐释术前NLR的预后价值。这项研究结果发表于2013年6月14日在线出版的《外科学年鉴》(Annals of Surgery)杂志上。该项回顾性研究共招募了

Neurology:脑缺血患者溶栓前中性粒细胞高,患者预后差

目的:为了确定缺血性卒中(IS)患者,静脉给予rtPA溶栓前,较高的中性粒细胞计数与症状性脑出血(sICH)和3月不良预后之间的关系。方法:在里尔和赫尔辛基群体研究中,给予IS患者rtPA治疗前,检测血液中白细胞,中性粒细胞以及淋巴细胞计数。主要终点为sICH(欧洲急性脑卒中Ⅱ定义)。次要终点为死亡以及3个月极好预后(mRS分数0-1或等于卒中前),良好预后(mRS分数为0-2或等于卒中前)。结果