Allergy:即使是健康足月婴儿,花粉暴露也会增加其呼吸道症状风险

2022-03-23 小文子 MedSci原创

在出生后第一年,花粉暴露与呼吸道症状风险增加有关。

花粉暴露与儿童和成人的呼吸道症状有关。然而,花粉暴露与婴儿期呼吸系统症状之间的相关性仍不清楚。Allergy杂志的一项研究探索了花粉暴露与婴儿期呼吸道症状的相关性,以及母亲特应症、婴儿性别或空气污染是否会改变这种联系。

研究调查了前瞻性出生队列BILD队列401名健康足月婴儿的14874个测量时间点。婴儿期,每周通过电话访谈评估白天和夜间的呼吸道症状(咳嗽、喘息、呼吸困难),用标准化的5分类严重程度评分(0-4)评估呼吸道症状的严重程度,0表示没有症状和评分≥1表明症状越来越严重。所有环境暴露(花粉浓度、PM2.5、NO2、温度、相对湿度)与婴儿居住地有关。评估花粉暴露与呼吸道症状之间的关系,以及母亲特应性、婴儿性别和空气污染(NO2、PM2.5)对效应的影响。空气污染数据仅在2005年1月1日至2017年1月1日期间可用,花粉数据仅限于这一时间段1月至9月。

结果显示,所有年份分析期间(1月~9月),日间呼吸道症状为0.13±0.13,夜间呼吸道症状为0.12±0.14。花粉暴露与日间呼吸道症状(10%花粉/m3:混合花粉RR=1.006[1.002,1.009];树花粉RR=1.005[1.002,1.008];草花粉RR=1.009[1.000,1.23])和夜间呼吸道症状(混合花粉1.003[0.999,1.007];树花粉1.003[0.999,1.007];草花粉1.014[1.004,1.024])增加有关。结果发现,混合花粉与母亲特应症和婴儿性别之间没有相互作用,但发现了混合花粉和PM2.5之间的复杂交互作用(p=0.002)。

在出生后第一年,花粉暴露与呼吸道症状风险增加有关,而与母亲特应症和婴儿性别无关。由于婴儿期是肺部发育特别脆弱的时期,花粉暴露的不良影响可能与儿童慢性哮喘的演变有关。

原文出处:

Amanda Gisler, Marloes Eeftens, et al, Pollen exposure is associated with risk of respiratory symptoms during the first year of life, Allergy, 2022, doi: 10.1111/ALL.15284.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2009579, encodeId=d8d820095e9a6, content=<a href='/topic/show?id=f63239e24eb' target=_blank style='color:#2F92EE;'>#呼吸道症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39724, encryptionId=f63239e24eb, topicName=呼吸道症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fca128, createdName=licz0423, createdTime=Thu Nov 17 11:28:19 CST 2022, time=2022-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1205217, encodeId=1f7c120521e82, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>花粉过敏患者,鼻炎, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Mar 23 13:57:09 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282579, encodeId=ef5212825e9de, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329607, encodeId=698f132960e06, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396456, encodeId=fd8d1396456cd, content=<a href='/topic/show?id=89f18693e6e' target=_blank style='color:#2F92EE;'>#花粉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86937, encryptionId=89f18693e6e, topicName=花粉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2009579, encodeId=d8d820095e9a6, content=<a href='/topic/show?id=f63239e24eb' target=_blank style='color:#2F92EE;'>#呼吸道症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39724, encryptionId=f63239e24eb, topicName=呼吸道症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fca128, createdName=licz0423, createdTime=Thu Nov 17 11:28:19 CST 2022, time=2022-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1205217, encodeId=1f7c120521e82, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>花粉过敏患者,鼻炎, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Mar 23 13:57:09 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282579, encodeId=ef5212825e9de, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329607, encodeId=698f132960e06, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396456, encodeId=fd8d1396456cd, content=<a href='/topic/show?id=89f18693e6e' target=_blank style='color:#2F92EE;'>#花粉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86937, encryptionId=89f18693e6e, topicName=花粉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=)]
    2022-03-23 Jessica

    #学习#花粉过敏患者,鼻炎

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2009579, encodeId=d8d820095e9a6, content=<a href='/topic/show?id=f63239e24eb' target=_blank style='color:#2F92EE;'>#呼吸道症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39724, encryptionId=f63239e24eb, topicName=呼吸道症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fca128, createdName=licz0423, createdTime=Thu Nov 17 11:28:19 CST 2022, time=2022-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1205217, encodeId=1f7c120521e82, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>花粉过敏患者,鼻炎, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Mar 23 13:57:09 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282579, encodeId=ef5212825e9de, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329607, encodeId=698f132960e06, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396456, encodeId=fd8d1396456cd, content=<a href='/topic/show?id=89f18693e6e' target=_blank style='color:#2F92EE;'>#花粉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86937, encryptionId=89f18693e6e, topicName=花粉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=)]
    2022-03-23 zhmscau
  4. [GetPortalCommentsPageByObjectIdResponse(id=2009579, encodeId=d8d820095e9a6, content=<a href='/topic/show?id=f63239e24eb' target=_blank style='color:#2F92EE;'>#呼吸道症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39724, encryptionId=f63239e24eb, topicName=呼吸道症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fca128, createdName=licz0423, createdTime=Thu Nov 17 11:28:19 CST 2022, time=2022-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1205217, encodeId=1f7c120521e82, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>花粉过敏患者,鼻炎, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Mar 23 13:57:09 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282579, encodeId=ef5212825e9de, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329607, encodeId=698f132960e06, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396456, encodeId=fd8d1396456cd, content=<a href='/topic/show?id=89f18693e6e' target=_blank style='color:#2F92EE;'>#花粉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86937, encryptionId=89f18693e6e, topicName=花粉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=)]
    2022-03-23 膀胱癌
  5. [GetPortalCommentsPageByObjectIdResponse(id=2009579, encodeId=d8d820095e9a6, content=<a href='/topic/show?id=f63239e24eb' target=_blank style='color:#2F92EE;'>#呼吸道症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39724, encryptionId=f63239e24eb, topicName=呼吸道症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fca128, createdName=licz0423, createdTime=Thu Nov 17 11:28:19 CST 2022, time=2022-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1205217, encodeId=1f7c120521e82, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>花粉过敏患者,鼻炎, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Mar 23 13:57:09 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282579, encodeId=ef5212825e9de, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329607, encodeId=698f132960e06, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396456, encodeId=fd8d1396456cd, content=<a href='/topic/show?id=89f18693e6e' target=_blank style='color:#2F92EE;'>#花粉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86937, encryptionId=89f18693e6e, topicName=花粉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Wed Mar 23 01:28:19 CST 2022, time=2022-03-23, status=1, ipAttribution=)]

相关资讯

Am J Resp Crit Care:MMP-7、呼吸道症状和死亡率之间的相关性分析!

由此可见,血清MMP-7水平可能是社区居住的成年人肺脏中亚临床细胞外基质重塑的定量生物标志物,这可能会易化亚临床ILD的研究。

2016JSPM临床指南——癌症患者呼吸道症状治疗建议发布

2016年6月,日本姑息医学会(JSPM)发布了癌症患者呼吸道症状治疗建议指南,该指南针对癌症患者呼吸道症状的管理共提出26条循证建议。全文获取:下载地址:指南下载 (需要扣积分2分, 梅斯医学APP免积分下载) 

EI:每周多用一次喷雾清洁剂,哮喘发生风险增加1.3%!

在大量家用清洁剂中,清洁产品对呼吸系统产生一系列不良影响。

Respir Med:在患有过敏性鼻炎的儿童和青少年中,运动诱导的支气管痉挛研究

运动后的呼吸道症状在鼻炎患者中是常见的。运动诱导的支气管痉挛(EIB)也许是其中的一种。最近,有研究人员评估了EIB在患有过敏性鼻炎的儿童和成年人中的流行程度,比较了跑台运动(TR)和EVH挑战,并且还评估了运动呼吸道症状和EIB。研究包括了年龄在10岁到20岁的患者。研究人员评估了过去几年鼻炎症状的严重度和运动相关的症状,并在随机顺序中进行了挑战,挑战不多于72个小时,并且遵从国际指南。在每次挑

NEJM:有保留肺功能的吸烟者就真的没有呼吸道症状了吗?

目前,慢性阻塞性肺疾病(COPD)的诊断需要1秒用力呼气容积(FEV1)与小于0.70的用力肺活量(FVC)(通过支气管扩张剂使用后通过肺活量评估)的比值来确定。然而,很多吸烟者不符合有呼吸道症状的定义。原始出处:Prescott G. Woodruff,Graham Barr,Eugene Bleecker,et al.Clinical Significance of Symptoms in S